Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain.

Nature Communications
Bernardo A MelloYuhai Tu

Abstract

Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of having multiple modification sites is also unclear. Here, we show that sequentially ordered methylation/demethylation is critical for perfect adaptation; adaptation accuracy decreases as randomness in the multisite methylation process increases. A tradeoff between adaptation accuracy and response gain is discovered. We find that this accuracy-gain tradeoff is lifted significantly by having more methylation sites, but only when the multisite modification process is sequential. Our study suggests that having multiple modification sites and a sequential modification process constitute a general strategy to achieve both accurate adaptation and high response gain simultaneously. Our theory agrees with existing data and predictions are made to help identify the molecular mechanism underlying ordered covalent modifications.

References

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T C TerwilligerD E Koshland
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·C Y Huang, J E Ferrell
Jun 26, 1997·Nature·N Barkai, S Leibler
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S DjordjevicA H West
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A Duke, D Bray
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·T M YiJ Doyle
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·Victor Sourjik, Howard C Berg
Apr 30, 2003·Biophysical Journal·Bernardo A Mello, Yuhai Tu
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bernardo A Mello, Yuhai Tu
Sep 4, 2004·Biophysical Journal·Bernardo A MelloYuhai Tu
Apr 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Steven Henikoff
Oct 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeremy Gunawardena
Nov 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bernardo A Mello, Yuhai Tu
Jan 1, 2008·Trends in Biochemical Sciences·Gerald L HazelbauerJohn S Parkinson
Jan 9, 2008·PLoS Computational Biology·Clinton H HansenNed S Wingreen
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuhai TuHoward C Berg
Oct 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cezar M KhursigaraSriram Subramaniam
Nov 4, 2010·Biophysical Journal·Yigal MeirNed S Wingreen
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ariane BriegelBrian R Crane
Jun 28, 2012·Nature Physics·Ganhui LanYuhai Tu
Jan 15, 2014·PloS One·Silke NeumannVictor Sourjik
Sep 26, 2015·Physical Review Letters·Pablo Sartori, Yuhai Tu
Jul 31, 2018·Annual Review of Condensed Matter Physics·Yuhai Tu, Wouter-Jan Rappel
Oct 28, 2019·Protein Science : a Publication of the Protein Society·Mingshan Li, Gerald L Hazelbauer

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