PMID: 2125331Nov 1, 1990Paper

Sequential monitoring of cytogenetic damage in rat lymphocytes following in vivo exposure to aflatoxin B1 and N-nitrosophenacetin

Mutation Research
S Y Li, J K Lin

Abstract

Rats were treated intraperitoneally with different concentrations of aflatoxin B1 (AFB1) or N-nitrosophenacetin (NP). Blood was sequentially drawn by venous puncture at 6, 24, 72, 120 h and 14 days after a single injection of AFB1 or NP. After AFB1 the frequency of SCEs and chromosome aberrations increased progressively and reached a maximum level after 24 h and then decreased with time. By 2 weeks post treatment, the SCE and chromosome aberration values were within the control range. A small but significant SCE induction was observed when rats were treated with NP, but no chromosome breakage was induced even at the highest dose (20 mg/kg). We suggest that the elimination of DNA damage by repair mechanisms and lymphocyte turnover is responsible for the reduction of SCEs and chromosome aberrations with time. This assay seems promising for sequential monitoring of cytogenetic damage in rat lymphocytes following in vivo exposure to genotoxicants.

References

Feb 1, 1976·Toxicology and Applied Pharmacology·T C Campbell, J R Hayes
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee
Sep 1, 1973·Cell and Tissue Kinetics·C Röpke, N B Everett
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·D A DolimpioM Legator
Jun 1, 1966·Gut·K R Rees

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