Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits.

Neuron
Erin L BarnhartThomas R Clandinin

Abstract

Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic processing? Here we used in vivo calcium imaging to identify pre- and postsynaptic mechanisms for processing local motion signals in global motion detection circuits in Drosophila. Lobula plate tangential cells (LPTCs) detect global motion by pooling input from local motion detectors, T4/T5 neurons. We show that T4/T5 neurons suppress responses to adjacent local motion signals whereas LPTC dendrites selectively amplify spatiotemporal sequences of local motion signals consistent with preferred global patterns. We propose that sequential nonlinear suppression and amplification operations allow optic flow circuitry to simultaneously prevent saturating responses to local signals while creating selectivity for global motion patterns critical to behavior.

Citations

Nov 12, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Huayi WeiClaude Desplan
Apr 6, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takahiro HinoManabi Fujiwara
Jun 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Malin, Claude Desplan

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