Sequential plasma lactate concentrations as prognostic indicators in adult equine emergencies

Journal of Veterinary Internal Medicine
B S Tennent-BrownR C Boston

Abstract

Sequential lactate concentration ([LAC]) measurements have prognostic value in that hospitalized humans and neonatal foals that have a delayed return to normolactatemia have greater morbidity and case fatality rate. Prognosis for survival is decreased in horses with a delayed return to normal [LAC]. Two hundred and fifty adult horses presented for emergency evaluation excepting horses evaluated because of only ophthalmologic conditions, superficial wounds, and septic synovitis without systemic involvement. Prospective observational study. [LAC] was measured at admission and then at 6, 12, 24, 48, and 72 hours after admission. The change in [LAC] over time ([LAC]deltaT) was calculated from changes in [LAC] between sampling points. Median [LAC] was significantly (P < .001) higher at admission in nonsurvivors (4.10 mmol/L [range, 0.60-18.20 mmol/L]) when compared with survivors (1.30 mmol/L [range, 0.30-13.90 mmol/L]) and this difference remained at all subsequent time points. The odds ratio for nonsurvival increased from 1.29 (95% confidence interval 1.17-1.43) at admission to 49.90 (6.47-384) at 72 hours after admission for every 1 mmol/L increase in [LAC]. [LAC]deltaT was initially positive in all horses but became negative and...Continue Reading

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Citations

Nov 19, 2011·Journal of Veterinary Internal Medicine·S Hashimoto-HillP H Kass
Sep 6, 2013·Journal of the American Veterinary Medical Association·David M WongWalter H Hsu
Jun 19, 2014·Journal of the American Veterinary Medical Association·Olga M Seco DíazVirginia B Reef
Jul 14, 2014·The Veterinary Clinics of North America. Equine Practice·Brett Tennent-Brown
Oct 15, 2013·Journal of Veterinary Internal Medicine·T KarapinarM Kom
Nov 1, 2012·Journal of Veterinary Emergency and Critical Care·Pedro De PedroRaymond C Boston
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Dec 27, 2016·Journal of Veterinary Internal Medicine·K MizenM-F Roy
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Jan 21, 2021·BMC Veterinary Research·Olga Witkowska-PiłaszewiczLucjan Witkowski
Mar 13, 2021·Journal of Veterinary Emergency and Critical Care·Alex Louis BlutingerJennifer Prittie
Mar 30, 2021·Frontiers in Veterinary Science·Alexander Valverde
Jul 17, 2021·Frontiers in Endocrinology·Darko StefanovskiRaymond C Boston
Jan 20, 2022·Journal of Veterinary Emergency and Critical Care·Rolfe M RadcliffeThomas J Divers

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