Sequential renal biopsies in insulin-dependent diabetic patients: structural factors associated with clinical progression

Kidney International
P FiorettoMichael Mauer

Abstract

Quantitative structural studies in native kidneys of IDDM patients have almost all been cross sectional, and little is known regarding the dynamics of progression of structural lesions in relation to clinical progression. It has been suggested that interstitial may be more important than glomerular changes in determining functional outcome. This study evaluated renal structure in sequential biopsies from IDDM patients with established renal lesions to determine whether glomerular, arteriolar and interstitial changes progress together and in concordance with measures of renal function. Eleven long-term IDDM patients [age 29 +/- 10 years, duration 17 +/- 7 years (mean +/- SD)] had renal function studies and kidney biopsies performed at two occasions 5.6 +/- 1.6 years apart. HbA1 as well as creatinine clearance (CCr) did not change over this time; albumin excretion rate (AER) increased from 12 (6 to 280) to 19 (5 to 2462) [median (range)] mg/24 hr (P < 0.03). AER increased in the three patients with abnormal albuminuria at first observation, and two normoalbuminuric patients became microalbuminuric. Blood pressure (BP) did not change; however, the number of patients on antihypertensive therapy increased from 1 to 5. All structural...Continue Reading

References

Jan 1, 1979·Journal of Microscopy·E B JensenR Osterby
Jun 6, 1987·British Medical Journal·H H ParvingP A Svendsen
Apr 1, 1986·Kidney International·E N EllisS M Mauer
Apr 1, 1973·The Tohoku Journal of Experimental Medicine·Y YamauchiY Goto
Oct 1, 1984·The Journal of Clinical Investigation·S M MauerF C Goetz
Mar 1, 1993·Kidney International·P H LaneS M Mauer
Sep 1, 1953·Diabetes·E T BELL

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Citations

Mar 31, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Dec 4, 2009·Current Diabetes Reports·Julia M Steinke
May 31, 2012·Current Diabetes Reports·Anil Karihaloo
Mar 10, 2000·Cytokine & Growth Factor Reviews·K Sharma, T A McGowan
Nov 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·K E WhiteUNKNOWN Diabiopsies Group
Sep 21, 2000·Kidney International. Supplement·E D Schleicher, C Weigert
Jul 9, 2003·Kidney International·Bruce L RiserDorothy Kahkonen
Jul 9, 1998·The New England Journal of Medicine·P FiorettoM Mauer
Dec 6, 2006·Journal of Asian Natural Products Research·C-Y HeZ-B Lin
Jan 25, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn SamnegårdMats Sjöquist
Aug 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria F Lopes-VirellaUNKNOWN DCCT/EDIC Research Group
Oct 22, 2004·Kidney International·Sharon Adler
Apr 22, 2008·International Journal of Clinical Practice·Y-L LinC-S Yang
Nov 13, 2004·American Journal of Nephrology·Susanne B NicholasYun Chon
Mar 5, 2005·American Journal of Nephrology·Mark E Williams
Sep 16, 2006·American Journal of Nephrology·Melpomeni PeppaJaime Uribarri
May 4, 2012·Toxicologic Pathology·Hernan Rincon-CholesJeffrey L Barnes
Apr 23, 2011·Journal of the American Society of Nephrology : JASN·Kumar SharmaJeffrey B Kopp
Jan 12, 2013·Journal of the American Society of Nephrology : JASN·Hassan N IbrahimMichael Mauer
Apr 13, 2013·The International Journal of Biochemistry & Cell Biology·María Del Nogal-ÁvilaMaría P Ruiz-Torres
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Changyong LuHelen Vlassara
Mar 20, 2003·Current Diabetes Reports·P FiorettoM Mauer
Aug 30, 2011·Critical Reviews in Clinical Laboratory Sciences·Marijn M SpeeckaertJoris R Delanghe
Nov 28, 2002·Experimental Animals·Toshiaki InenagaYasuhiro Yoshikawa
Sep 6, 2000·Kidney International·K V LemleyR G Nelson
Aug 31, 2007·Kidney International·M H A BaccoraJ Yee
Dec 17, 2008·Diabetes Research and Clinical Practice·Behzad Najafian, Michael Mauer
Nov 14, 2008·Diabetes Research and Clinical Practice·Tatsumi MoriyaYoshikuni Fujita
Mar 18, 2008·Diabetes Research and Clinical Practice·Tatsumi MoriyaYoshikuni Fujita
Jan 27, 2015·Journal of Diabetes Investigation·Yoshiro MaezawaKoutaro Yokote
May 23, 2015·BioMed Research International·Mervi E HyvönenSanna Lehtonen
Sep 4, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael MauerBehzad Najafian
Apr 30, 2002·Diabetes·Keith DrummondUNKNOWN International Diabetic Nephropathy Study Group

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