PMID: 7524606Nov 1, 1994Paper

Sequential resection of residual abdominal and thoracic masses after chemotherapy for metastatic non-seminomatous germ cell tumours

British Journal of Cancer
A GerlW Wilmanns

Abstract

Thirty-eight patients with advanced non-seminomatous germ cell tumours (NSGCTs) underwent multiple surgical interventions (two in 33 patients, three in four patients, four in one patient) after cisplatin-based chemotherapy. All patients had normal serum tumour markers but persistent radiographic masses. The larger mass was routinely resected first. Fifteen patients (39%) had dissimilar histological findings at sequential surgical procedures, 12 of whom demonstrated less favourable pathological features during the first operation and three at the second. Patients who underwent both retroperitoneal lymph node dissection (RPLND) and lung resection showed less favourable histological features in the retroperitoneum in nine cases and in the lung in three cases. Eight of 16 patients (50%) without mature teratoma in their primary tumours showed complete necrosis/fibrosis at all surgical interventions, whereas all patients whose primary tumour was classified as malignant teratoma intermediate demonstrated mature teratoma at least at one anatomical site. As histology of post-chemotherapy residual masses cannot be extrapolated from one anatomical site to another, patients usually are properly managed by excision of all residual masses. I...Continue Reading

Citations

Nov 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karin OechsleUNKNOWN German Multicenter Positron Emission Tomography Study Group
Apr 18, 2009·World Journal of Urology·Brett S Carver, Joel Sheinfeld
Nov 1, 2013·ANZ Journal of Surgery·Homayoun ZargarAlan I So
Sep 24, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Mototsugu MuramakiSadao Kamidono
Nov 19, 2004·Der Pathologe·V LoyJ Linke
Jul 26, 2005·Annals of Surgery·Jörg Thomas HartmannCarsten Bokemeyer
Jul 24, 2003·European Urology·Peter AlbersStefan C Müller
May 9, 2007·The Urologic Clinics of North America·Hong Gee SimDaniel W Lin

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