Sequential restoration of external limiting membrane and ellipsoid zone after intravitreal anti-VEGF therapy in diabetic macular oedema.

Eye
Somnath DeLevent Akduman

Abstract

To study the mechanism of restoration of retinal photoreceptor ellipsoid zone (EZ), after intravitreal bevacizumab (IVB) therapy, in diabetic macular oedema (DMO). Forty-four consecutive patients aged 40-65 years having type 2 diabetes mellitus (DM) with DMO were prospectively recruited for IVB therapy. It comprised of three doses (1.25 mg in 0.05 ml) of IVB at monthly intervals. Patients with other ocular and systemic diseases affecting retinal vessels and earlier ophthalmological interventions were excluded. Visual acuity (logMAR VA) was recorded. Spectral domain optical coherence tomography (SD-OCT) was performed pre and post intervention. Central sub-foveal thickness (CST) and grades of disorganization of retinal inner layers (DRIL), external limiting membrane (ELM) and EZ were assessed. Data were statistically analysed on SPSS software. Clinical trials registry: CTRI/2019/03/018135. Mean logMAR VA decreased after IVB therapy from 1.78 ± 0.07 pre-intervention to 0.42 ± 0.05 post intervention (p < 0.001). Similarly, CST reduced from 354.23 ± 15.0 µm pre-intervention to 233.18 ± 7.88 µm post intervention (p < 0.001). Among qualitative variables, DRIL decreased from 93.2% pre-intervention to 13.6% post intervention. Likewise, ...Continue Reading

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Citations

Mar 6, 2021·International Journal of Retina and Vitreous·Sandeep SaxenaCarsten H Meyer
Jun 3, 2021·Journal of Personalized Medicine·Sagnik SenSobha Sivaprasad
Jun 12, 2021·Experimental Biology and Medicine·Xincheng YaoDavid Le
Jun 17, 2021·European Journal of Ophthalmology·Sandeep SaxenaLevent Akduman
Aug 6, 2021·Clinical Ophthalmology·Patricia UdaondoJosé María Ruiz-Moreno
Oct 13, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Verónica Castro-NavarroEnrique Cervera-Taulet
Oct 29, 2021·Indian Journal of Ophthalmology·Sandeep Saxena, SriniVas R Sadda

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