Abstract
The authors report the unique response of two patients treated for cystoid macular edema (CME) secondary to central retinal vein occlusion (CRVO) who developed sequential episodes of likely sterile inflammatory responses following separate intravitreal injections of aflibercept (Eylea; Regeneron, Tarrytown, NY) and ranibizumab (Lucentis; Genentech, South San Francisco, CA) despite multiple previous uneventful injections for CME secondary to CRVO. Following the twenty-fifth aflibercept and seventh ranibizumab injection, two patients developed an acute inflammatory response, which was treated empirically with intravitreal antibiotics and topical and oral steroids (in Case 2). After an 8- to 10-week hiatus, they were switched over to ranibizumab and aflibercept, respectively, following which they developed a second episode of intraocular inflammation, treated similarly. Vitreous culture in one and aqueous culture in the other were deemed to represent contamination. Sterile intraocular inflammation, a known risk following injection with either aflibercept or ranibizumab, may develop sequentially in the same patient despite switching the drug. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:428-431.].
References
Jun 1, 1996·Current Eye Research·K C ChernC Y Lowder
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Jan 3, 2009·Ophthalmology·David M BrownUNKNOWN ANCHOR Study Group
Mar 17, 2009·Retina·Ioannis D LadasIoannis Vergados
Apr 30, 2011·The New England Journal of Medicine·UNKNOWN CATT Research GroupGlenn J Jaffe
Aug 2, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Christine N KayStephen R Russell
May 5, 2012·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupFrederick L Ferris
May 7, 2013·Ophthalmology·Paul HahnUNKNOWN American Society of Retina Specialists Therapeutic Surveillance Committee
Dec 7, 2013·Mediators of Inflammation·Shivi AgrawalJohn B Christoforidis
Jun 13, 2014·BMJ Case Reports·Jodi A GladingDevaraj Supramaniam
Jul 2, 2014·American Journal of Ophthalmology·Roger A GoldbergJeffrey S Heier
Jun 14, 2013·Retinal Cases & Brief Reports·Matthew A CunninghamStephen R Russell
Jan 16, 2015·JAMA Ophthalmology·Paul HahnPravin U Dugel
Mar 31, 2016·Ophthalmic Research·Sibel DemirelEmin Özmert
Apr 27, 2016·Retina·Patrick D WilliamsDavid Callanan
Citations
Sep 18, 2018·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Jan 14, 2021·Survey of Ophthalmology·Maram E A Abdalla Elsayed, Igor Kozak
Feb 22, 2021·Vestnik oftalmologii·O D OstroumovaL K Moshetova