Sequential stimulation of nuclear RNA polymerase activities in livers from thyroidectomized rats treated with triiodothyronine.

Endocrinology
A ViarengoM Orunesu

Abstract

A single ip injection of triiodothyronine (T3; 30 mug/100 g BW) to thyroidectomized rats markedly stimulates RNA synthesis in isolated liver nuclei. The increased level of RNA synthesized in vitro by isolated nuclei does not depend on a reduced degradation of the nascent RNA molecules, since ribonuclease activities are not affected by the administration of T3. In addition, our results have confirmed previous findings of Tata et al. that the increase in nucleolar alpha-amanitin-resistant RNA polymerase I activity at low ionic strength always preceded the rise of the nucleoplasmic alpha-amanitin-sensitive RNA polymerase II activity at high ionic strength. Moreover, it has been found that a significant increase in an alpha-amanitin-resistant activity at high ionic strength occurs as early as 10 h after hormone injection. This enzyme, which forms RNA with a U to G ratio significantly higher than that of RNA synthesized by the nucleolar alpha-amanitin-resistant enzyme, is probably nucleoplasmic RNA polymerase III which is though to synthesize 5S and transfer RNAs. The possible role and the mechanism(s) of the early and concomitant increase in nucleolar and nucleoplasmic alpha-aminitin-resistant activities, and of the subsequent rise...Continue Reading

Citations

Apr 1, 1983·In Vitro·E FugassaA Cordone
Oct 30, 1985·Biochimica Et Biophysica Acta·G GalloM Orunesu
Mar 1, 1977·Molecular and Cellular Endocrinology·K YoshizatoN Shioya
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Jan 25, 1979·The New England Journal of Medicine·K Sterling
Mar 1, 1977·Clinical Endocrinology·J Bernal, S Refetoff
Jan 1, 1990·Fundamental & Clinical Pharmacology·T BienvenuG Olive
Jan 15, 1982·Experientia·E FugassaR Accomando
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Jan 1, 1978·Journal of Endocrinological Investigation·L J DeGrootA H Coleoni
Jan 1, 1981·The American Journal of Physiology·D E PeavyL S Jefferson
Mar 9, 1979·Science·J H Oppenheimer

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