PMID: 8944457Oct 1, 1996Paper

Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure

The British Journal of Surgery
A J BothaA W Goode

Abstract

Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet-activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1.26(0.19), 1.33(0.26), 1.04(0.14) and 0.86(0.13) nmol superoxide per min per 1.3 x 10(6) neutrophils respectively (P < 0.05). Priming at 3 h after injury was inhibited by mean(s.e.m.) 63.8(7.0) per cent by the PAF antagonist, WEB 2170 (P < 0.01). Mean(s.e.m.) plasma IL-8 was raised at 6 and 12 h after injury to 785(183) and 836(175) pg/ml (P < 0.01). At 12 h after injury the plasma IL-8 level correlated directly with the number of units of red blood cells transfused (r = 0.64, P < 0.01), and was significantly higher in the group of six patients who developed MOF (P < 0.05). These data suggest that after trauma the mediators PAF and IL-8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL-8 may also be an early biochemical marker predicting the onset of MOF.

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Citations

Nov 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G EngelichK L Hartshorn
May 30, 2001·Critical Care Medicine·D A PartrickF A Kuypers
Mar 15, 2006·The Journal of Trauma·Raj BhatiaIan Pallister
Feb 14, 2007·The Journal of Trauma·Naoyuki HashiguchiWolfgang G Junger
Jul 19, 2008·Shock·Vanessa NomelliniElizabeth J Kovacs
Dec 25, 2004·American Journal of Respiratory and Critical Care Medicine·Michael H TarloweCarl J Hauser
May 17, 2001·Journal of Neurosurgery·B WolachM Schlesinger
Jul 29, 2005·Intensive Care Medicine·Christian LaplaceJacques Duranteau
Jul 7, 2005·Injury·Raj K BhatiaNicholas Topley
Jun 22, 2005·Cytokine & Growth Factor Reviews·Ana L CoelhoSteven L Kunkel
May 25, 1999·The Journal of Trauma·H OguraH Sugimoto
Nov 24, 1999·The Journal of Trauma·C J HauserE A Deitch
Apr 29, 1998·The Journal of Trauma·D A PartrickC C Silliman
Dec 29, 2000·The Journal of Trauma·J M AdamsE A Deitch
Mar 20, 2002·Shock·Ulrich C LienerFlorian Gebhard
Apr 23, 2004·The Journal of Biological Chemistry·Glenn E BrownMichael B Yaffe
Jan 6, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael BlanksteinEmil H Schemitsch
Nov 28, 2002·Current Opinion in Critical Care·Patrick T MurrayCiro Tetta
Mar 27, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L JosephM Hauer-Jensen
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana L CoelhoSteven L Kunkel

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