Sequential therapy for 10 days versus triple therapy for 14 days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial

Gut
Jyh-Ming LiouTaiwan Gastrointestinal Disease and Helicobacter Consortium

Abstract

Significant heterogeneity was observed in previous trials that assessed the efficacies of sequential therapy for 10 days (S10) versus triple therapy for 14 days (T14) in the first-line treatment of Helicobacter pylori. We aimed to compare the efficacy of S10 and T14 and assess the factors affecting their efficacies. We conducted this open-label randomised multicentre trial in eight hospitals and one community in Taiwan. 1300 adult subjects with H pylori infection naïve to treatment were randomised (1:1) to receive S10 (lansoprazole and amoxicillin for the first 5 days, followed by lansoprazole, clarithromycin and metronidazole for another 5 days) or T14 (lansoprazole, amoxicillin and clarithromycin for 14 days). All drugs were given twice daily. Successful eradication was defined as negative 13C-urea breath test at least 6 weeks after treatment. Our primary outcome was the eradication rate by intention-to-treat (ITT) and per-protocol (PP) analyses. Antibiotic resistance was determined by agar dilution test. The eradication rates of S10 and T14 were 87.2% (567/650, 95% CI 84.4% to 89.6%) and 85.7% (557/650, 95% CI 82.8% to 88.2%) in the ITT analysis, respectively, and were 91.6% (556/607, 95% CI 89.1% to 93.4%) and 91.0% (548/60...Continue Reading

Associated Clinical Trials

References

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Citations

Jan 15, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Changcheng GuoZhenghong Chen
May 4, 2017·Helicobacter·Javier P Gisbert, Adrian G McNicholl
Jun 2, 2018·Minerva medica·Vincenzo SavarinoEdoardo Savarino
Dec 4, 2016·Hematology·Michael Auerbach, Thomas Deloughery
Jan 28, 2020·Journal of Gastroenterology and Hepatology·Jyh-Ming LiouMing-Shiang Wu
Dec 31, 2019·Frontline Gastroenterology·Ammar Al-RifaieMo Thoufeeq
Jul 17, 2020·Journal of Gastroenterology and Hepatology·Tsung-Hsien ChiangYi-Chia Lee
Mar 30, 2017·Canadian Journal of Gastroenterology & Hepatology·Masafumi MaruyamaKendo Kiyosawa
Sep 12, 2017·Helicobacter·Anthony O'ConnorColm O'Morain
Sep 2, 2018·The American Journal of Gastroenterology·Mei-Jyh ChenUNKNOWN Taiwan Gastrointestinal Disease Helicobacter Consortium
Oct 5, 2018·Journal of Biomedical Science·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Apr 19, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJoaquim Prado de Moraes-Filho
Aug 16, 2016·The Kaohsiung Journal of Medical Sciences·Cheng-En TsaiSeng-Kee Chuah
Dec 17, 2015·Alimentary Pharmacology & Therapeutics·J-M LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jan 15, 2017·Journal of Gastroenterology and Hepatology·Yi-Chia Lee, Jaw-Town Lin
Aug 18, 2016·Helicobacter·Anthony O'ConnorColm O'Morain
Sep 30, 2017·The Journal of Antimicrobial Chemotherapy·Mei-Jyh ChenUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
May 31, 2018·The Journal of Antimicrobial Chemotherapy·Jyh-Ming LiouUNKNOWN Members of the Taiwan Gastrointestinal Disease and Helicobacter Consortium
Apr 19, 2016·Journal of Gastroenterology and Hepatology·Jyh-Ming LiouJaw-Town Lin
Nov 17, 2017·European Journal of Clinical Investigation·Rocco Maurizio ZagariFranco Bazzoli
Aug 22, 2020·Therapeutic Advances in Gastroenterology·Chieh-Chang ChenUNKNOWN and for the Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jul 26, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJosé Vitor Zir
Jul 28, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jeffrey S ChangLi-Tzong Chen
Jan 21, 2021·Gut and Liver·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Mar 23, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Da-Jyun SuJia-Feng Wu
Jul 3, 2018·Gastroenterology·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jul 24, 2020·Minerva medica·Rocco M ZagariFranco Bazzoli
Jun 8, 2021·The Korean Journal of Internal Medicine·Hye-Kyung JungUNKNOWN Korean College of Helicobacter and Upper Gastrointesinal Research

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Methods Mentioned

BETA
biopsy
Genotyping

Clinical Trials Mentioned

NCT01607918

Software Mentioned

Desmos Graph Calculator
SPSS

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