Sequential therapy of abiraterone and enzalutamide in castration-resistant prostate cancer: a systematic review and meta-analysis.

Prostate Cancer and Prostatic Diseases
Keiichiro MoriShahrokh F Shariat

Abstract

This systematic review and meta-analysis aimed to assess the prognostic value of sequential of abiraterone (ABI) and enzalutamide (ENZ) therapy in patients with castration-resistant prostate cancer (CRPC). PUBMED, Web of Science, Cochrane Library, and Scopus databases were searched for articles published prior to December 2019 according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Studies were deemed eligible if they compared overall survival (OS), combined progression-free survival (PFS), combined prostate specific antigen (PSA)-PFS, and PSA response rates in CRPC patients receiving sequential ABI/ENZ or vice versa. PSA response to both the first and second agents was defined as a >50% decrease in PSA achieved with each of these agents. Formal meta-analyses were performed for these outcomes. Ten studies with 1096 patients were eligible for the systematic review and eight studies with 643 patients for the meta-analysis. The ABI-to-ENZ sequence was significantly associated with better PFS (pooled hazard ratio (HR): 0.62, 95% confidential interval (CI): 0.49-0.78, P < 0.001), and PSA-PFS (pooled HR: 0.48, 95% CI: 0.38-0.61, P < 0.001) than the ENZ-to-ABI sequence. PSA response rates of both ...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 23, 2003·Health Technology Assessment : HTA·J J DeeksUNKNOWN European Carotid Surgery Trial Collaborative Group
Jun 30, 2006·Contemporary Clinical Trials·Rebecca DerSimonian, Raghu Kacker
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
Aug 13, 2011·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleni EfstathiouChristopher J Logothetis
Aug 17, 2012·The New England Journal of Medicine·Howard I ScherUNKNOWN AFFIRM Investigators
Dec 12, 2012·The New England Journal of Medicine·Charles J RyanUNKNOWN COU-AA-302 Investigators
Jun 3, 2014·The New England Journal of Medicine·Tomasz M BeerUNKNOWN PREVAIL Investigators
Jun 3, 2014·European Urology·Eleni EfstathiouChristopher J Logothetis
Jun 24, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ChiF Saad
Apr 30, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki TeradaEmmanuel S Antonarakis
Jan 1, 2017·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Koichi MiyamaeYasuyuki Hamada
Oct 1, 2019·The New England Journal of Medicine·Ronald de WitUNKNOWN CARD Investigators

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Citations

Jul 23, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rahul R AggarwalJoshi J Alumkal
Jul 15, 2020·Biochemical Pharmacology·Axel H SchönthalFrancis S Markland
Apr 15, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rana R McKayMary-Ellen Taplin

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