Abstract
Squamous cell carcinoma (SCC) of the buccal mucosa is aggressive and requires multimodal treatment. The objective of this study was to evaluate the outcome of sequential therapy (neoadjuvant therapy plus surgery plus radiotherapy) in advanced buccal SCC and explore the prognostic factors. In this retrospective cohort study, patients with advanced buccal cancer who received neoadjuvant chemotherapy (cisplatin, docetaxel, and 5-fluorouracil) followed by surgery and radiotherapy in the authors' department were reviewed. The outcomes of chemotherapy and surgery were analyzed. Overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. The prognostic values of age, gender, histologic grade, lymph node status, tumor stage, pathologic response, and adverse pathologic features were explored using the log-rank test and the Cox regression model. From 2008 to 2011, data from 22 patients were analyzed. The overall response rate of chemotherapy was 72.7%. The pathologic complete or partial response rate was 40.9%. The median follow-up was 36 months. The 2-year DFS and OS rates were 63.3% and 67.2%, respectively. Male and younger patients showed an association with poor outcome. Multivariate analysis ...Continue Reading
References
Oct 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R C MishraT K Mishra
May 4, 2001·Anti-cancer Drugs·H M WangI H Chen
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa LicitraGiulio Cantù
May 4, 2004·The British Journal of Oral & Maxillofacial Surgery·E Mathew IypeM Krishnan Nair
Oct 4, 2005·Head & Neck·Chun-Shu LinWeng-Yoon Shum
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Kang-Hsing FanJoseph Tung-Chieh Chang
Mar 13, 2008·Journal of Surgical Oncology·K A PathakA A Abdoh
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Chien-Yu LinJoseph Tung-Chieh Chang
Sep 2, 2008·International Journal of Oral and Maxillofacial Surgery·K A PathakR Bhalavat
Jan 18, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jih-Chuan JanI-Fan Chen
Oct 20, 2011·Head & Neck·Merrill S KiesErich M Sturgis
Jan 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jingeng LiuJianhua Fu
Mar 19, 2013·World Journal of Surgical Oncology·Jie MaLai-ping Zhong