Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance.

Antimicrobial Agents and Chemotherapy
A ChauzyJ M Buyck

Abstract

Experiments were conducted with polymyxin B and two Klebsiella pneumonia isogenic strains (the wild type, KP_WT, and its transconjugant carrying the mobile colistin resistance gene, KP_MCR-1) to demonstrate that conducting two consecutive time-kill experiments (sequential TK) represents a simple approach to discriminate between pharmacokinetics/pharmacodynamics models with two heterogeneous subpopulations or adaptive resistance.

References

Jan 5, 2002·Journal of Pharmacokinetics and Pharmacodynamics·S L Beal
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Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Jeffrey J CampionMartin E Evans
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Jun 28, 2013·Pharmacological Reviews·Elisabet I Nielsen, Lena E Friberg
May 11, 2016·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann

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Citations

Jun 1, 2021·International Journal of Antimicrobial Agents·Gauri G Rao, Cornelia B Landersdorfer

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