Sequential transformation of t(8;13)-related disease: a case report

Acta Haematologica
S RoyS Juneja

Abstract

We report a case of an atypical myeloproliferative disorder with t(8;13) that presented as B-lineage acute lymphoblastic leukaemia (B-ALL). Following induction chemotherapy, the disease manifested as chronic myeloproliferative state, which responded to hydroxyurea. Terminally, the disease transformed into acute myeloid leukaemia (AML) with additional chromosomal abnormalities including monosomy 7. To our knowledge, this is the first case of this rare atypical myeloproliferative disorder with t(8;13) that presented as B-ALL and terminally transformed to AML with additional chromosomal abnormalities.

Citations

Dec 29, 2007·The American Journal of Surgical Pathology·Francisco VegaLynne V Abruzzo
Aug 2, 2006·European Journal of Haematology·Katsuya YamamotoToshimitsu Matsui
Jul 9, 2003·British Journal of Haematology·Barbara J Bain
Jun 22, 2010·Journal of Pediatric Hematology/oncology·Xiangli ChenLinxiang Liu

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