PMID: 7535760Jan 1, 1994Paper

Sequential transplants using mobilized peripheral blood progenitor cells

Journal of Clinical Apheresis
R GhalieR Pierre

Abstract

Modest success has been achieved with the use of high-dose cytotoxic therapy and bone marrow transplantation in solid tumors. Patient outcome can potentially be improved with further intensification of the therapy. The rapid hematologic recovery achieved with mobilized peripheral blood progenitor cells (PBPC) may reduce the toxicity of transplantation enabling the use of sequential courses of myeloablative therapy. We report on 42 patients with solid tumors enrolled in a tandem transplant protocol involving the use of PBPC mobilized with cyclophosphamide (4 g/m2), etoposide (1 g/m2), and granulocyte-colony-stimulating factor (G-CSF: 10 micrograms/kg/day). This regimen significantly increased the number of circulating progenitor cells; only 1-2 aphereses were sufficient to collect 2.5 x 10(8)/kg mononuclear cells, our goal for each transplant course. The median number of circulating colony-forming units (CFU) and CD34+ cells obtained for each transplant course were 70.3 x 10(4)/kg, and 11.7 x 10(6)/kg, respectively. There was a significant correlation between the numbers of CD34+ cells and CFU measured in the apheresis product (r = 0.49, P = .003). The first transplant regimen given to 38 patients consisted of thiotepa, carbopla...Continue Reading

References

Jan 1, 1992·Journal of Hematotherapy·J G BenderL S Schwartzberg
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K AntmanL E Schnipper
Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R DunphyR O Wallerstein
May 3, 1986·Lancet·A J BellT J Hamblin
May 3, 1986·Lancet·P Selby, A Horwich

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