Sequentially-crosslinked biomimetic bioactive glass/gelatin methacryloyl composites hydrogels for bone regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Jiafu ZhengXiaofeng Chen

Abstract

In recent years, gelatin-based composites hydrogels have been intensively investigated because of their inherent bioactivity, biocompatibility and biodegradability. Herein, we fabricated photocrosslinkable biomimetic composites hydrogels from bioactive glass (BG) and gelatin methacryloyl (GelMA) by a sequential physical and chemical crosslinking (gelation + UV) approach. The results showed that the compressive modulus of composites hydrogels increased significantly through the sequential crosslinking approach. The addition of BG resulted in a significant increase in physiological stability and apatite-forming ability. In vitro data indicated that BG/GelMA composites hydrogels promoted cell attachment, proliferation and differentiation. Overall, the BG/GelMA composites hydrogels combined the advantages of good biocompatibility and bioactivity, and had potential applications in bone regeneration.

Citations

Apr 30, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Peng XiaYifu Sun
Feb 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Man LuoXiaofeng Chen
Jan 31, 2021·International Journal of Biological Macromolecules·Himansh GoelAditi Bhattacharya
Dec 10, 2020·Materials·Rachele SergiValeria Cannillo
Nov 17, 2020·Biomedical Materials·Anna KozelskayaSergei Tverdokhlebov
Jan 28, 2021·Tissue Engineering. Part a·Negar RajabiFilippo Berto
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Miao ShiXiaofeng Chen
Jun 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meng-Na LiYa-Ping Guo
Dec 16, 2020·ACS Biomaterials Science & Engineering·Robin AugustineJessiya Jacob
Sep 25, 2021·Journal of Biomedical Materials Research. Part a·Mahmoud A SakrKeekyoung Kim
Jan 7, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuai WuHong Li

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