Sequestration of drugs using poly(acrylic acid) and alkyl modified poly(acrylic acid) nanoparticles

Soft Matter
Soma Chakraborty, P Somasundaran

Abstract

Poly(acrylic acid) and alkyl modified poly(acrylic acid) nanoparticles were formed by the reverse microemulsion technique. Scanning electron microspectroscopy, zeta potential measurements and fluorescence spectroscopy were used for their characterization. It was observed that they are in the range 80-100 nm and their surface charge is pH dependent. The particles were assessed for their ability to extract drugs such as amitriptyline and bupivacaine from bulk fluid for their potential application as scavengers for overdosed drugs. In normal saline (0.9% NaCl) unmodified poly(acrylic acid) nanoparticles (per gram) extracted 81 mg amitriptyline and 62 mg bupivacaine in 5 minutes, whereas for the alkyl modified poly(acrylic acid) nanoparticles, extractions were 68 mg and 51 mg amitriptyline and bupivacaine respectively per gram of nanoparticles used.

References

Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Mar 17, 2001·Advanced Drug Delivery Reviews·S SakumaM Akashi
Jun 9, 2001·International Journal of Pharmaceutics·C H LeeY Lee
Dec 14, 2002·International Journal of Pharmaceutics·Yongmei Xu, Yumin Du
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudaxshina Murdan
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jae Hyung ParkSeo Young Jeong
Mar 19, 2004·Journal of Medicinal Chemistry·Thomas L AndresenKent Jørgensen
Jun 17, 2004·Journal of the American Chemical Society·Yemin LiuTheresa M Reineke
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang YooSeo Young Jeong
Feb 24, 2005·International Journal of Pharmaceutics·A VilaM J Alonso
May 17, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ana GrenhaCarmen Remuñán-López
Jul 20, 2005·Molecular Pharmaceutics·Makoto YuasaHiroyoshi Kawakami

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Citations

Feb 23, 2012·Scientific Reports·Eric Y ChenWei-Chun Chin
Mar 20, 2019·Physical Chemistry Chemical Physics : PCCP·Aruna K MoraSukhendu Nath
Oct 17, 2014·Science Translational Medicine·Vincent ForsterJean-Christophe Leroux
Jun 5, 2015·Science Translational Medicine·Vincent Forster, Jean-Christophe Leroux
Oct 14, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Brett A Howell, Anuj Chauhan
Apr 15, 2016·The Journal of Physical Chemistry. B·Aruna K MoraSukhendu Nath
Sep 6, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Anna BogomolovaSergey K Filippov

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