Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats

PloS One
Syed Faraz KazimKhalid Iqbal

Abstract

Autism is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal and non-verbal communication skills as well as restricted interests and repetitive behavior. It has been hypothesized that altered brain environment including an imbalance in neurotrophic support during early development contributes to the pathophysiology of autism. Here we report that sera from children with autism which exhibited abnormal levels of various neurotrophic factors induced cell death and oxidative stress in mouse primary cultured cortical neurons. The effects of sera from autistic children were rescued by pre-treatment with a ciliary neurotrophic factor (CNTF) small peptide mimetic, Peptide 6 (P6), which was previously shown to exert its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing brain derived neurotrophic factor (BDNF) expression. Similar neurotoxic effects and neuroinflammation were observed in young Wistar rats injected intracerebroventricularly with autism sera within hours after birth. The autism sera injected rats demonstrated developmental delay and deficits in social communication, interaction, and novelty. Both the neurobiological changes and t...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1979·European Journal of Pharmacology·R G Browne
Nov 1, 1975·Animal Behaviour·J Altman, K Sudarshan
Mar 1, 1975·Developmental Psychobiology·G L Oswalt, G W Meier
Jan 1, 1976·Analytical Biochemistry·A Bensadoun, D Weinstein
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·M S Blumberg, J R Alberts
May 1, 1974·Developmental Psychobiology·R W BellT A Zachman
Jan 1, 1971·Developmental Psychobiology·J T Allin, E M Banks
Apr 1, 1965·Animal Behaviour·W M Fox
Apr 1, 1980·Journal of Comparative and Physiological Psychology·M A Hofer, H Shair
Mar 1, 1996·Developmental Medicine and Child Neurology·P GuerinG Lelord
Jan 1, 1996·Progress in Neurobiology·M EbadiM D Baxi
Jun 10, 1998·Brain : a Journal of Neurology·A BaileyP Lantos
Aug 5, 1998·Journal of Neuropathology and Experimental Neurology·T L Kemper, M Bauman
Aug 13, 1998·Journal of Neural Transmission. Supplementum·B Hutter-PaierM Windisch
Dec 8, 2000·Experimental Animals·H NaitoJ Makino
Jan 6, 2001·Neuron·C LordD G Amaral
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheil MoonGabriele V Ronnett
Jul 27, 2002·Molecular Psychiatry·T L Kemper, M L Bauman
Oct 9, 2002·Current Protein & Peptide Science·Z Y ChenZ Y Yan
Oct 19, 2002·Science·R Douglas Fields, Beth Stevens-Graham
Jan 17, 2003·Stem Cells·Donald Metcalf
Jan 31, 2003·Acta Neuropathologica·Yoshitaka TatebayashiInge Grundke-Iqbal
Feb 14, 2003·Current Neurology and Neuroscience Reports·Maria T Acosta, Phillip L Pearl
Mar 20, 2003·Behavioural Brain Research·Dóra ReglodiIstván Lengvári
May 7, 2003·Neuroscience and Biobehavioral Reviews·Susan L Andersen
May 7, 2003·Neuroscience and Biobehavioral Reviews·Igor BranchiLaura Ricceri
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Eric CourchesneNatacha Akshoomoff
Feb 24, 2004·Journal of Hematotherapy & Stem Cell Research·María del Carmen Cárdenas-AguayoLuis Covarrubias
May 29, 2004·Brain & Development·Kaoru MiyazakiMasaaki Narita

❮ Previous
Next ❯

Citations

Feb 3, 2016·Frontiers in Cellular Neuroscience·Janet K KernMark R Geier
Nov 10, 2015·Journal of Theoretical Biology·Md Nasrul IslamMd Tamjidul Hoque
Jul 30, 2015·Neurochemistry International·X Du, R A Hill
Feb 1, 2017·Journal of Autism and Developmental Disorders·Amene Saghazadeh, Nima Rezaei
Jun 6, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Natascia BrondinoPierluigi Politi
Oct 26, 2018·Inflammatory Bowel Diseases·Kimi DrobinJonas Halfvarson

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
phase contrast microscopy

Software Mentioned

Multi Gauge
GraphPad Prism
EZ
GraphPad
Maze
C1 Viewer Image
ANY
Ultravox
NIH Image J
SPSS

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
H WeiXiaohong Li
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
J M MountzH G Liu
The Journal of the Kentucky Medical Association
P G Williams, A S Bloom
© 2021 Meta ULC. All rights reserved