PMID: 3746310Jul 1, 1986Paper

Sera from patients with motor neuron disease and associated paraproteinaemia fail to inhibit experimentally induced sprouting of motor nerve terminals

Journal of Neurology, Neurosurgery, and Psychiatry
M Donaghy, L W Duchen

Abstract

IgG kappa paraproteinaemia was discovered in one patient with amyotrophic lateral sclerosis and one with chronic spinal muscular atrophy. Serum from these patients was injected into mouse muscles paralysed by botulinum toxin which is known to induce sprouting from motor nerve terminals. Daily injection of serum for 7 days failed to inhibit terminal sprouting. It is concluded that the paraproteins did not recognise a growth factor postulated as being implicated in the pathogenesis of motor neuron disease.

References

Jan 1, 1967·American Journal of Clinical Pathology·T NambaD Grob
Jan 1, 1968·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·L W Duchen, S J Strich
Sep 1, 1982·Annals of Neurology·W H ShermanL P Rowland
Oct 11, 1984·The New England Journal of Medicine·M E GurneyJ P Antel
May 1, 1983·Muscle & Nerve·J R SlackS Pockett
Sep 1, 1980·The Journal of Physiology·M C BrownR Ironton

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Citations

Aug 1, 1989·Annals of Neurology·D B Drachman, R W Kuncl
Jul 18, 2006·Journal of the Neurological Sciences·Michael Donaghy

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