Serendipitous discovery and X-ray structure of a human phosphate binding apolipoprotein

Structure
R MoralesEric Chabrière

Abstract

We report the serendipitous discovery of a human plasma phosphate binding protein (HPBP). This 38 kDa protein is copurified with the enzyme paraoxonase. Its X-ray structure is similar to the prokaryotic phosphate solute binding proteins (SBPs) associated with ATP binding cassette transmembrane transporters, though phosphate-SBPs have never been characterized or predicted from nucleic acid databases in eukaryotes. However, HPBP belongs to the family of ubiquitous eukaryotic proteins named DING, meaning that phosphate-SBPs are also widespread in eukaryotes. The systematic absence of complete genes for eukaryotic phosphate-SBP from databases is intriguing, but the astonishing 90% sequence conservation between genes belonging to evolutionary distant species suggests that the corresponding proteins play an important function. HPBP is the only known transporter capable of binding phosphate ions in human plasma and may become a new predictor of or a potential therapeutic agent for phosphate-related diseases such as atherosclerosis.

References

Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Jan 1, 1991·Research in Microbiology·D B Young, T R Garbe
Nov 9, 1989·The New England Journal of Medicine·D J Gordon, B M Rifkind
Mar 1, 1988·Computer Applications in the Biosciences : CABIOS·E W Myers, W Miller
Aug 13, 1971·Biochimica Et Biophysica Acta·N Medveczky, H Rosenberg
Jul 1, 1994·Proteins·L Holm, C Sander
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S LedvinaF A Quiocho
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Jan 1, 2000·Arthritis and Rheumatism·S BlässG R Burmester
Dec 2, 2000·Cellular and Molecular Neurobiology·O RiahP Courrière
Sep 22, 2001·Acta Crystallographica. Section D, Biological Crystallography·A PerrakisV S Lamzin
Sep 25, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·W K WeebaddaM A Hayes
Jun 25, 2002·The Journal of Biological Chemistry·Denis JossePatrick Masson
Jul 24, 2002·FEBS Letters·Anne BernaBruno Stuhlmüller
Sep 11, 2002·Angewandte Chemie·Sergey V Dorozhkin, Matthias Epple
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter M Jones, Anthony M George
Jul 4, 2003·The Journal of Nutrition·Michael BelenkyStephen Barnes
Dec 4, 2003·Acta Crystallographica. Section D, Biological Crystallography·A FokineE Chabriere
Apr 22, 2004·American Journal of Physiology. Renal Physiology·Vivek KumarJohn C Lieske
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Jan 1, 1996·Acta Crystallographica. Section D, Biological Crystallography·J P Abrahams, A G Leslie
Dec 21, 2004·Free Radical Biology & Medicine·Philip W ConnellyGraham F Maguire
Apr 13, 2005·Atherosclerosis·Bianca FuhrmanMichael Aviram
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Carlos Contreras-MartelEric Chabrière

❮ Previous
Next ❯

Citations

Jan 11, 2014·The Journal of Physical Chemistry. B·Mathias GruberClaus Hélix-Nielsen
Jul 11, 2007·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Sebastien MoniotEric Chabriere
Feb 20, 2008·PLoS Pathogens·Olga ZaborinaJohn C Alverdy
Feb 18, 2010·PloS One·Jean-Marc CollombetEric Chabrière
Dec 21, 2010·Journal of Synchrotron Radiation·Mikael EliasEric Chabriere
Jul 19, 2011·Virology Journal·Thomas CherrierChristian Schwartz
Mar 18, 2009·Cellular and Molecular Life Sciences : CMLS·Anne BernaAndrew Suh
Jun 8, 2013·Cellular and Molecular Life Sciences : CMLS·François Bernier
Nov 15, 2008·Biological Chemistry·Antimo Di MaroMaria Rosaria Faraone-Mennella
Jul 7, 2007·FEBS Letters·Soyeon AhnKen Scott
Jul 28, 2012·Research in Microbiology·Geneviève BallAlain Filloux
Mar 9, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Mar 17, 2011·Advances in Chronic Kidney Disease·Clemens Bergwitz, Harald Jüppner
Mar 21, 2007·The International Journal of Biochemistry & Cell Biology·Anne BernaKen Scott
Apr 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne BernaFrançois Bernier
Sep 10, 2009·Journal of Cellular Physiology·Shohreh AminiNune Darbinian
Apr 13, 2010·Acta Crystallographica. Section D, Biological Crystallography·Karthik S Paithankar, Elspeth F Garman
Apr 6, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Frédérique RenaultDaniel Rochu
Mar 15, 2006·Structure·Martin R Webb
Apr 3, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Ahmed DjeghaderEric Chabriere
Apr 4, 2009·Journal of Cellular Biochemistry·Nune DarbinianShohreh Amini
Apr 2, 2013·Nature·Bjørn P PedersenRobert M Stroud
Jun 6, 2017·Acta Crystallographica. Section F, Structural Biology Communications·Vanessa R PegosMikael Elias
Jun 23, 2020·Biochemistry. Biokhimii︠a︡·V A AleshinV I Bunik
Nov 23, 2007·Biochemical Society Transactions·D RochuP Masson
Oct 24, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nader SalariShervin Shabani
Mar 7, 2021·International Journal of Molecular Sciences·Elena PorzioGiuseppe Manco
Apr 6, 2021·Journal of Bioscience and Bioengineering·Christine L GeeAlexander McPherson
May 19, 2009·Journal of the American Chemical Society·Dorothee LiebschnerEric Chabrière

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.