Serendipitous discovery of an immunoglobulin-binding autotransporter in Bordetella species.

Infection and Immunity
Corinne L WilliamsPeggy A Cotter

Abstract

We describe the serendipitous discovery of BatB, a classical-type Bordetella autotransporter (AT) protein with an approximately 180-kDa passenger domain that remains noncovalently associated with the outer membrane. Like genes encoding all characterized protein virulence factors in Bordetella species, batB transcription is positively regulated by the master virulence regulatory system BvgAS. BatB is predicted to share similarity with immunoglobulin A (IgA) proteases, and we showed that BatB binds Ig in vitro. In vivo, a Bordetella bronchiseptica DeltabatB mutant was unable to overcome innate immune defenses and was cleared from the lower respiratory tracts of mice more rapidly than wild-type B. bronchiseptica. This defect was abrogated in SCID mice, suggesting that BatB functions to resist clearance during the first week postinoculation in a manner dependent on B- and T-cell-mediated activities. Taken together with the previous demonstration that polymorphonuclear neutrophils (PMN) are critical for the control of B. bronchiseptica in mice, our data support the hypothesis that BatB prevents nonspecific antibodies from facilitating PMN-mediated clearance during the first few days postinoculation. Neither of the strictly human-ada...Continue Reading

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Citations

Mar 13, 2014·Nature Reviews. Microbiology·Jeffrey A MelvinPeggy A Cotter
Jul 6, 2014·Expert Review of Vaccines·James D Cherry, Christopher D Paddock
Apr 1, 2016·Clinical Microbiology Reviews·Paul E KilgoreHeinz-Josef Schmitt
Jul 18, 2020·Journal of Proteome Research·Jakub NovakPeter Sebo

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