PMID: 8952613Sep 1, 1996Paper

Serendipity or luck: stumbling on gingival crevicular fluid

Journal of Dental Research
B KRASSE

Abstract

The word "serendipity" comes from the tale "The Three Princes from Serendip" by Horace Walpole. It is defined as an aptitude for making fortunate discoveries accidentally." The demonstration of crevicular fluid was truly an accidental discovery. Niels Brill, a successful private practitioner in Copenhagen with prosthodontics as a specialty, and Bo Krasse, associate professor of cariology, were examining the microflora of gingival pockets in a dog. Before the samples were taken, gingiva and teeth were disinfected with an iodine solution. The solution disappeared from different pockets at different speeds. After intravenous injection of a fluorescein solution, the occurrence of fluorescein could be recorded on filter paper strips. Thus, after stumbling on the disappearance of iodine from the cervical areas of the teeth, two non-periodontologists managed to demonstrate why it disappeared. This article describes the details of the discovery and subsequent studies, and offers some reflections by one of the original authors 37 years later.

References

Apr 1, 1992·Journal of Periodontology·R C Page
May 1, 1986·Journal of Clinical Periodontology·D H Fine, I D Mandel
Nov 1, 1983·Journal of Clinical Periodontology·F RohnerP Vuagnat
Aug 1, 1994·Journal of Clinical Periodontology·C A McCulloch
May 1, 1994·Journal of Periodontology·I B LamsterJ T Grbic
Feb 1, 1995·Periodontology 2000·I B Lamster, J T Grbic
Apr 1, 1992·Journal of Periodontology·Roy C Page
May 1, 1994·Journal of Periodontology·Ira B LamsterJohn T Grbic

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Citations

Dec 15, 2015·Periodontology 2000·Silvana P BarrosThiago Morelli
Dec 15, 2015·Periodontology 2000·Rebecca R Wassall, Philip M Preshaw
Apr 27, 2004·Periodontology 2000·Nicolas Delaleu, Matthias Bickel
Mar 27, 2003·Periodontology 2000·Andrew J Delima, Thomas E Van Dyke

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