PMID: 2096406Jan 1, 1990Paper

Serenics fluprazine (DU 27716) and eltoprazine (DU 28853) enhance neophobic and emotional behaviour in mice

Psychopharmacology
G GriebelJ R Martin

Abstract

Two tests designed to elicit responses to novelty and to aversive stimuli were used to study the effects of the serenics fluprazine and eltoprazine on the behaviour of male Swiss mice: a free exploratory test (fluprazine; 2.5, 5 and 10 mg/kg; eltoprazine: 2.5, 5, 10 and 15 mg/kg) and a two-box choice procedure (fluprazine: 1.25, 2.5, 5 and 7.5 mg/kg; eltoprazine: 2.5, 5, 7.5 and 10 mg/kg). Both drugs increased the neophobic reaction, as well as the avoidance of a brightly illuminated box. These effects closely resemble those of psychostimulant drugs such as methamphetamine and caffeine. It is hypothesized that the behavioural changes induced by these drugs may be due to a nonspecific increase of the emotional reactivity of animals.

References

Jan 1, 1989·Psychopharmacology·B OlivierJ Hartog
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·H A Baldwin, S E File
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D Treit
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·C BelzungE Vogel
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·C BelzungG Chapouthier
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·S E FileL J Wilks
Jan 1, 1985·Psychopharmacology·B OlivierR van Oorschot
Jan 1, 1985·Psychopharmacology·K J FlannellyR J Blanchard
Feb 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·R N Hughes
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Dec 1, 1983·Behavioural Brain Research·D BentonV Grimm
Jan 1, 1981·Psychopharmacology·R Misslin, P Ropartz

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Citations

Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·J M Rawleigh, E D Kemble
Apr 1, 1995·Pharmacology & Therapeutics·S L Handley
Dec 1, 1992·Brain Research Bulletin·J L MoreauW E Haefely
Sep 1, 1996·Behavioural Processes·M E Albonetti, F Farabollini
Jul 15, 1998·Neuroscience and Biobehavioral Reviews·D C BlanchardR J Blanchard
Jan 3, 2007·Neuroscience and Biobehavioral Reviews·Robert N Hughes

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