Serial 18F-choline-PET imaging in patients receiving enzalutamide for metastatic castration-resistant prostate cancer: response assessment and imaging biomarkers.

Future Oncology
Francesca MainesEnzo Galligioni

Abstract

High rate of non-target lesions in metastatic castration-resistant prostate cancer usually limits applicability of Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and this has led to a growing interest in using PET/computed tomography (CT). We prospectively investigated the role of (18)F-choline (FCH)-PET/CT in patients receiving enzalutamide after docetaxel. 30 patients were monitored by means of FCH-PET/CT before and during the treatment. A Cox proportional hazards regression model was used to assess the associations between metabolic parameters and clinical outcomes. Univariate analysis showed no significant correlation between biochemical and FCH-PET responses. Multivariate analysis showed that only baseline maximum standardized uptake value (SUVmax) significantly correlated with biochemical progression-free survival, radiological progression-free survival and overall survival. Our findings suggest that FCH-PET/CT may play a role in defining prognosis of patients receiving enzalutamide because baseline SUVmax proved to be an independent prognostic factor.

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Jun 10, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Tiziano GrazianiStefano Fanti
Apr 18, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gary Jr Cook, Vicky Goh
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Aug 26, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
Feb 23, 2020·Frontiers in Oncology·Anthony TurpinNicolas Penel
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May 18, 2020·Abdominal Radiology·Steven P RoweSpencer C Behr
Oct 4, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francesco CeciStefano Fanti

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Methods Mentioned

BETA
imaging technique

Software Mentioned

PERCIST
MedCalc
SPSS

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