Serial analysis of gene expression: ESTs get smaller

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
M D Adams

Abstract

Measuring gene expression on a global scale has been one of the vexing problems of cell biology. Velculescu et al.(1) recently proposed a system for identifying gene expression levels based on very short sequence tags-about nine base pairs-located at a specific site within a gene transcript. By coupling the strategy to current automated sequencing machines and the large expressed sequence tag databases, it should be possible to follow changes in gene expression for large numbers of genes economically and accurately.

References

Jul 24, 1987·Science·G VeresC T Caskey
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·N H LeeA R Kerlavage

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Citations

Oct 11, 2003·Biotechnology Advances·C C Xiang, Y Chen
Feb 20, 1998·Current Opinion in Genetics & Development·S Rastan, L J Beeley
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis
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Jun 1, 2004·Inflammatory Bowel Diseases·Klaartje KokPieter H Reitsma

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