Serial angiographic assessment of coronary artery obstruction and collateral flow in acute myocardial infarction. Report from the second Mount Sinai-New York University Reperfusion Trial

Circulation
K P RentropJ C Thornton

Abstract

In the Second Mt. Sinai-New York University Reperfusion Trial, in which change of ejection fraction was the primary end point, the following secondary end points were prospectively assessed by serial coronary angiography: patency of the infarct artery both before intervention and 10-14 days later, acute and delayed recanalization rates, presence or absence of collateral flow, and complication rates of acute interventional catheterization. We assigned 393 patients randomly to groups receiving acute cardiac catheterization and a double-blind intracoronary infusion of streptokinase (SK arm), both streptokinase and nitroglycerin (SK-NTG arm), nitroglycerin alone (NTG arm), or conventional therapy without acute catheterization (control arm). Prospective stratification was based on duration of infarct pain before randomization: group A, less than 2 hours; Group B, 2-12 hours. Baseline patency rates were comparable in patients studied within 6 hours (30%, 40 of 135) and those studied later (24%, 32 of 133). This finding refutes the hypothesis that spontaneous recanalization occurs frequently after 6 hours. The acute recanalization rates of the SK arm (60%, 40 of 67) and the SK-NTG arm (63%, 29 of 62) did not differ. During streptokina...Continue Reading

References

Apr 1, 1988·The American Journal of Cardiology·K P RentropM Van Buskirk
Nov 1, 1971·Progress in Cardiovascular Diseases·W Schaper
Dec 1, 1971·Journal of Clinical Pathology·H R MillarA L Stalker
Mar 24, 1972·Deutsche medizinische Wochenschrift·D Sinapius
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang

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Citations

Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
Apr 1, 1992·Cardiovascular Drugs and Therapy·M Verstraete
Oct 1, 1989·Journal of the American College of Cardiology·B SteinJ H Chesebro
Dec 1, 1990·Journal of the American College of Cardiology·J Van LierdeF Van de Werf
Dec 1, 1990·Journal of the American College of Cardiology·E Braunwald
Dec 1, 1990·Journal of the American College of Cardiology·G S Reeder
Jan 1, 1993·Journal of the American College of Cardiology·M FujitaS Sasayama
Apr 1, 1996·Journal of the American College of Cardiology·K KodamaA Hirayama
Aug 29, 1997·International Journal of Cardiology·J C NicolauS A Garzon
Nov 3, 2001·Journal of the American College of Cardiology·C LabinjohD J Webb
Feb 1, 1991·Journal of the American College of Cardiology·T BehrenbeckR J Gibbons
Mar 1, 1992·Journal of the American College of Cardiology·S RouxE Lüdin
Apr 10, 2002·Acta Anaesthesiologica Scandinavica·B OsterlundB Biber
Feb 1, 2006·Lab Animal·Imo E HoeferMarco M Jost
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Aug 7, 2010·Southern Medical Journal·Koichiro OkuharaMasao Yoshizumi
Dec 1, 1993·Australian and New Zealand Journal of Medicine·F Van de Werf
Feb 1, 1993·Journal of Cardiovascular Electrophysiology·E PattersonR Lazzara
Nov 4, 1995·Journal of Interventional Cardiology·G C Timmis, E Terrien
Feb 22, 2001·Annual Review of Physiology·I Baumgartner, J M Isner
Jun 23, 2009·American Journal of Respiratory and Critical Care Medicine·John D MaclayWilliam Macnee
Nov 22, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jasveen J Kandhai-RagunathClemens von Birgelen
Dec 7, 2000·Coronary Artery Disease·M J MasonC D Ilsley
Oct 20, 2004·Coronary Artery Disease·Robert D Smith, Charles D J Ilsley
Jul 8, 2005·Coronary Artery Disease·Hasan TurhanIrfan Sabah
Dec 4, 1992·Annals of the New York Academy of Sciences·E Falk
Apr 4, 2007·Journal of Thrombosis and Haemostasis : JTH·K JoodT Hrafnkelsdóttir
Nov 26, 2008·Acta Anaesthesiologica Scandinavica·B OsterlundB Biber
May 12, 2010·Acta Anaesthesiologica Scandinavica·R H LieT T Nielsen

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