Nov 17, 2009

Serial cardiopulmonary exercise testing in patients with previous Fontan surgery

Pediatric Cardiology
Susan M FernandesJonathan Rhodes

Abstract

Patients with previous Fontan surgery have reduced peak oxygen consumption (Vo 2), and data regarding progression of exercise intolerance is limited. The purpose of this study was to assess the evolution of exercise tolerance in patients with previous Fontan surgery. We performed a retrospective cohort study of patients with previous Fontan surgery who underwent cardiopulmonary exercise testing between November 2002 and January 2009. Patients were required to have completed at least two tests, with adequate levels of effort, >or-6 months apart. We identified 78 patients (55% male) who had undergone a total of 215 cardiopulmonary exercise tests. Age at initial study was 19.7 +/- 10.2 years; time interval since previous Fontan surgery 13.3 +/- 5.7 years; and time interval between the initial and the most recent exercise test was 3.0 +/- 1.4 years. Morphologic left ventricle was present in 58 (74.4%) patients. At baseline, peak Vo 2 averaged 24.7 +/- 7.0 ml/kg/min (63.7% +/- 15.8% predicted). At most recent study, peak Vo 2 averaged 23.2 +/- 7.2 ml/kg/min, (60.4% +/- 13.9% predicted). Percent predicted peak Vo 2 declined slowly, with a mean rate of decline of 1.25 +/- 0.36 percentage points/y (p < 0.001). Most of the decline occur...Continue Reading

  • References17
  • Citations34

References

  • References17
  • Citations34

Mentioned in this Paper

Impaired Exercise Tolerance
Left Ventricular Structure
Log-Linear Models
Science of Morphology
Exercise Tolerance
Cardiopulmonary Exercise Test
Hemi-Fontan Procedure
Exercise Stress Test
Congenital Heart Defects
Multivariate Analysis

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