Serial change in 123I-MIBG myocardial scintigraphy in non-insulin-dependent diabetes mellitus

Annals of Nuclear Medicine
S NagamachiShigeru Matsukura

Abstract

We performed 123I-MIBG (MIBG) myocardial scintigraphy twice in patients with non-insulin-dependent diabetes mellitus (NIDDM) to investigate whether MIBG distribution was improved by pertinent clinical control. To determine the influential factors for MIBG distribution, we investigated the association between various clinical parameters and the serial change in MIBG uptake parameters. Twenty NIDDM patients with no cardiac disorders were evaluated. Planar images were taken at 30 minutes (early) and 3 hours (delayed) after MIBG injection. The heart-to-upper-mediastinum uptake ratio (H/M) and washout ratio (WR) were calculated as parameters for estimating cardiac sympathetic function. Patients were divided into two groups, eight in the improved group and twelve in the unimproved group, according to the serial change in H/M. The mean interval between the baseline and the follow up study was 2.1 +/- 0.6 year. Differences between the means of the laboratory data in patients in both groups were compared for the baseline and the follow up study by using the paired t-test. As a means of determining the influential factors for a serial change of MIBG uptake, Fisher's exact test was performed to evaluate the association between the serial ...Continue Reading

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Citations

Feb 9, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Shigeki NagamachiHideyuki Wakamatsu
Jul 9, 2004·Annals of the New York Academy of Sciences·David S Goldstein
Mar 15, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bennett B ChinJohn W Babich

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