Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention

JACC. Cardiovascular Imaging
Kaori InoueYukio Ozaki

Abstract

This study sought to assess, by serial computed tomography angiography (CTA), the effect of statin treatment on coronary plaque morphology. In addition to the assessment of luminal stenosis, CTA also allows characterization of plaque morphology. Large, positively remodeled plaques with large necrotic cores have been reported as indicators of plaque instability. CTA was performed in 32 patients (26 men, ages 64.3 +/- 8.5 years). Of these, 24 received fluvastatin after the baseline study; 8 subjects who refused statin treatment were followed as the control subjects. Serial imaging was performed after a median interval of 12 months. All vessels were examined in every subject, and a 10-mm-long segment was identified for comparison before and after intervention. Total plaque volume, low attenuation plaque (LAP) volume, lumen volume, and remodeling index were calculated. In the statin-treated patients, the total plaque volume (92.3 +/- 37.7 vs. 76.4 +/- 26.5 mm(3), p < 0.01) and LAP volume (4.9 +/- 7.8 vs. 1.3 +/- 2.3 mm(3), p = 0.01) were significantly reduced over time; however, there was no change in the lumen volume (63.9 +/- 25.3 vs. 65.2 +/- 26.2 mm(3), p = 0.59). On the other hand, no change was observed in the CTA characteris...Continue Reading

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Citations

Oct 31, 2012·Cardiovascular Intervention and Therapeutics·Sadako MotoyamaYukio Ozaki
Jan 27, 2012·European Heart Journal Cardiovascular Imaging·Francis R JoshiJames H F Rudd
Nov 19, 2011·International Journal of Clinical Practice·R RajaniD S Berman
May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sei KomatsuKazuhisa Kodama
Oct 6, 2011·The Tohoku Journal of Experimental Medicine·Jiyoon SungSejoong Kim
Dec 25, 2013·Nihon Hoshasen Gijutsu Gakkai zasshi·Tomonari Sano
Sep 26, 2013·Radiology·Marcus R Makowski, René M Botnar
Jan 31, 2014·Current Atherosclerosis Reports·Robert S Fenning, Robert L Wilensky
Jun 5, 2014·The International Journal of Cardiovascular Imaging·Shinichiro FujimotoFrank J Rybicki
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Michael H CriquiMatthew A Allison
Mar 26, 2013·Current Cardiovascular Imaging Reports·Alan C KwanDavid A Bluemke
Feb 2, 2012·Expert Review of Cardiovascular Therapy·Jennifer M Malpeso, Matthew J Budoff
Mar 31, 2012·Expert Review of Cardiovascular Therapy·Yu KataokaStephen J Nicholls
Aug 30, 2013·Expert Review of Cardiovascular Therapy·Damini DeyStephan Achenbach
Sep 4, 2015·The International Journal of Cardiovascular Imaging·Peter J PsaltisDennis T L Wong
Mar 26, 2014·Journal of Cardiovascular Computed Tomography·Hideya YamamotoUNKNOWN PREDICT Investigators
Jan 23, 2016·Radiology Research and Practice·Sunny GoelOn Chen
Dec 15, 2015·The International Journal of Cardiovascular Imaging·Makoto AmanumaShinichi Takase
Jun 28, 2013·Thrombosis and Haemostasis·Gian Marco RosaFabrizio Montecucco
Oct 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki KawaiYukio Ozaki
Jun 1, 2014·The American Journal of Cardiology·Jagat Narula, William C Roberts
Nov 26, 2013·Atherosclerosis·Pranvera IbrahimiMichael Y Henein
Mar 21, 2012·JACC. Cardiovascular Imaging·Stella-Lida PapadopoulouPim J de Feyter
Jan 28, 2017·Journal of Cardiovascular Computed Tomography·Hui GuBin Lu
Oct 25, 2016·JACC. Cardiovascular Imaging·Amir Ahmadi, Jagat Narula
Feb 19, 2017·Journal of Cardiovascular Computed Tomography·Nobuo TomizawaSunao Nakamura
Jul 22, 2017·Nature Reviews. Drug Discovery·Bennett G ChildsJan M van Deursen
Feb 24, 2016·Angiology·Chadi AyoubBenjamin J W Chow
May 30, 2015·Clinical Medicine Insights. Cardiology·Sherif W AyadReem H Laymouna
Aug 5, 2017·Coronary Artery Disease·Rine NakanishiMatthew J Budoff

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