Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine

JACC. Basic to Translational Science
Nienke S van DitzhuijzenEvelyn Regar

Abstract

Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding of early atherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronary computed tomography angiography did not detect early atherosclerosis, but optical coherence tomography and near-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.

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Citations

Jan 12, 2020·Cardiovascular Research·Oana SoropDirk J Duncker
Jan 15, 2020·Cell and Tissue Research·Simone RennerEckhard Wolf
May 1, 2021·International Journal of Molecular Sciences·Holly J WoodwardVictoria E MacRae

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