PMID: 6171799Jan 1, 1981Paper

Serial electrophysiological studies in a young patient with recurrent ventricular fibrillation

Pacing and Clinical Electrophysiology : PACE
B BelhassenS Laniado

Abstract

A 28-year-old male with recurrent episodes of ventricular fibrillation, which were initiated by very early ventricular premature depolarizations with a normal QT interval, was subjected to three consecutive electrophysiological studies. During the first study, which was carried out to test the efficacy of amiodarone treatment, no ventricular arrhythmias could be induced. While on amiodarone therapy, the patient experienced another syncopal episode and therefore a second electrophysiological study was done. In that study, ventricular fibrillation was induced by ventricular stimulation. During the third study, which was carried out in order to evaluate the effect of the addition of quinidine to the on-going amiodarone therapy, no more than three repetitive ventricular responses could be induced. The patient has been asymptomatic since the third study (fifteen months) with combined therapy of amiodarone and quinidine. The significance of the ability to induce ventricular fibrillation during an electrophysiological study is discussed as well as the value of such studies in determining the long-term efficacy of antiarrhythmic drug therapy.

Citations

Mar 15, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Stephan WillemsDaniel Steven
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bernard Belhassen
Apr 16, 2013·Journal of the American College of Cardiology·Sami ViskinRaphael Rosso
Jun 1, 1993·Journal of Cardiovascular Electrophysiology·B Belhassen, S Viskin
Jun 1, 1994·Circulation·C R Coggins
Jul 4, 2018·Arrhythmia & Electrophysiology Review·Oholi Tovia BrodieBernard Belhassen
Jun 22, 2021·European Heart Journal·Martijn H van der Ree, Pieter G Postema

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