Serial interferon-gamma release assays after chemoprophylaxis in a tuberculosis outbreak cohort.

Infection
Sei Won LeeJ-J Yim

Abstract

Interferon-gamma release assay (IGRA) results have been suggested as a surrogate marker of treatment response in latent tuberculosis infection (LTBI). However, data have not been consistent, and most previous studies focused on participants taking isoniazid prophylaxis. The aim of this study was to elucidate the changes in the IGRA results in patients who underwent chemoprophylaxis with isoniazid and rifampicin daily for 3 months. In a TB outbreak cohort, 26 asymptomatic close contacts with normal chest radiographs and positive QuantiFERON-TB Gold In-Tube assay (QFT-GIT) results were recruited. These patients were treated with isoniazid and rifampicin daily for 3 months. The QFT-GIT was repeated at 3 and 6 months following treatment initiation. Compared with the initial QFT-GIT results (3.59 ± 3.39 IU/mL), the interferon-gamma (IFN-γ) levels had decreased significantly at 6 months (0.84 ± 1.14 IU/mL; P = 0.005), but not at 3 months (3.58 ± 3.64 IU/mL; P = 0.98). Reversions occurred in seven (26.9 %) patients at 3 months and in an additional two participants at 6 months; a total of nine participants (34.6 %) had reversions. Recent conversion was associated with reversion of the test results (odds ratio 26.3, 95 % confidence inte...Continue Reading

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Citations

Dec 5, 2012·Chest·Deepak AggarwalPrasanta Raghab Mohapatra
Jan 7, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwang-Sook WooKyeong-Hee Kim
Jun 3, 2014·The Tohoku Journal of Experimental Medicine·Kwang Won SeoYangjin Jegal
Aug 26, 2014·Journal of the International Association of Providers of AIDS Care·Andrea T CruzJeffrey R Starke
Apr 4, 2017·Japanese Journal of Infectious Diseases·Thana KhawcharoenpornAnucha Apisarnthanarak
Dec 31, 2019·Journal of Immunology Research·Eleane de OyarzabalMartha Torres
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Oct 6, 2020·Frontiers in Immunology·Claudia CarranzaMartha Torres
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Nov 27, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Qingluan YangWenhong Zhang

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