Serial lactate and admission SOFA scores in trauma: an analysis of predictive value in 724 patients with and without traumatic brain injury

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
C DübendorferM Turina

Abstract

Arterial lactate, base excess (BE), lactate clearance, and Sequential Organ Failure Assessment (SOFA) score have been shown to correlate with outcome in severely injured patients. The goal of the present study was to separately assess their predictive value in patients suffering from traumatic brain injury (TBI) as opposed to patients suffering from injuries not related to the brain. A total of 724 adult trauma patients with an Injury Severity Score (ISS) ≥ 16 were grouped into patients without TBI (non-TBI), patients with isolated TBI (isolated TBI), and patients with a combination of TBI and non-TBI injuries (combined injuries). The predictive value of the above parameters was then analyzed using both uni- and multivariate analyses. The mean age of the patients was 39 years (77 % males), with a mean ISS of 32 (range 16-75). Mortality ranged from 14 % (non-TBI) to 24 % (combined injuries). Admission and serial lactate/BE values were higher in non-survivors of all groups (all p < 0.01), but not in patients with isolated TBI. Admission SOFA scores were highest in non-survivors of all groups (p = 0.023); subsequently septic patients also showed elevated SOFA scores (p < 0.01), except those with isolated TBI. In this group, SOFA s...Continue Reading

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Citations

Feb 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Ingo Marzi
Aug 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jean-Louis VincentFabio S Taccone
Oct 16, 2016·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S E DekkerC Boer
Sep 6, 2018·Biology of Reproduction·Julia ZöllnerMark R Johnson
Sep 15, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Anirban BhattacharjeeMohd Yunus
Sep 21, 2016·The Journal of Trauma and Acute Care Surgery·Christopher T LewisMark J Midwinter
Mar 8, 2019·Journal of Orthopaedic Surgery and Research·Chia-Peng ChangCheng-Ting Hsiao

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