Serial lung function and elastic recoil 2 years after lung volume reduction surgery for emphysema

Chest
A F GelbM J Schein

Abstract

To evaluate serial lung function studies, including elastic recoil, in patients with severe emphysema who undergo lung volume reduction surgery (LVRS). To determine mechanism(s) responsible for changes in airflow limitation. We studied 12 (10 male) patients aged 68+/-9 years (mean+/-SD) 6 to 12 months prior to and at 6-month intervals for 2 years after thoracoscopic bilateral LVRS for emphysema. At 2 years post-LVRS, relief of dyspnea remained improved in 10 of 12 patients, and partial or full-time oxygen dependency was eliminated in 2 of 7 patients. There was significant reduction in total lung capacity (TLC) compared with pre-LVRS baseline, 7.8+/-0.6 L (mean+/-SEM) (133+/-5% predicted) vs 8.6+/-0.6 L (144+/-5% predicted) (p=0.003); functional residual capacity, 5.6+/-0.5 L (157+/-9% predicted) vs 6.7+/-0.5 L (185+/-10% predicted) (p=0.001); and residual volume, 4.9+/-0.5 L (210+/-16% predicted) vs 6.0+/-0.5 L (260+/-13% predicted) (p=0.000). Increases were noted in FEV1, 0.88+/-0.08 L (37+/-6% predicted) vs 0.72+/-0.05 L (29+/-3% predicted) (p=0.02); diffusing capacity, 8.5+/-1.0 mL/min/mm Hg (43+/-3% predicted) vs 4.2+/-0.7 mL/min/mm Hg (18+/-3% predicted) (p=0.001); static lung elastic recoil pressure at TLC (Pstat), 13.7+/...Continue Reading

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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Francis C Cordova, Gerard J Criner
Dec 10, 1999·The Annals of Thoracic Surgery·J HamacherW Weder
Jun 1, 2000·Australian and New Zealand Journal of Medicine·S H PorterS Homan
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Oct 4, 2006·Current Opinion in Anaesthesiology·B Mets
Oct 6, 2006·Current Opinion in Anaesthesiology·Edmond Cohen
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Feb 24, 2001·Clinics in Chest Medicine·K R Flaherty, F J Martinez
Apr 25, 2000·Current Problems in Surgery·J B ShragerJ D Edelman

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