PMID: 8980844Nov 1, 1996Paper

Serial magnetic resonance imaging in children with postinfectious encephalitis

Brain & Development
S KimuraS Uehara

Abstract

We analyzed follow-up magnetic resonance images (MRI) in eight children with clinical postinfectious encephalitis (PIE), and discussed their pathogeneses. Three categories of MRI findings were apparent: (1) multifocal lesions in the white matter with/without basal ganglia involvement consistent with acute disseminated encephalomyelitis (ADEM) (three patients); (2) single or multifocal lesions localized only in the gray matter (two patients); and (3) localized lesions in the brain stem, basal ganglia or cerebellum. Some lesions in the patients in Categories 1 and 2 migrated or were resolved quickly, sometimes within 10 days. Gadolinium caused linear or spotty enhancement in the patients in Category 2. These findings suggest that Categories 1 and 2 are a self-limiting allergic angiopathy without demyelination. In contrast, the lesions in the patients in Category 3 were fixed, and not resolved within 6 months (three patients). The pathogenesis of Category 3 is not known. All except one patient had no prednisolone (PSL) therapy, however; all lesions were resolved completely or markedly reduced in size, which indicates PSL therapy is not always necessary in patients with PIE.

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Citations

Nov 3, 2005·Current Neurology and Neuroscience Reports·Cornelia Mihai, Burk Jubelt
Feb 28, 2001·Brain & Development·K L HungM L Tsai
Mar 14, 2002·Brain & Development·Shu-ichi ItoShumpei Yokota
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Aug 4, 2009·International Journal of Systematic and Evolutionary Microbiology·Hidetoshi MoritaMasahira Hattori
Mar 31, 2009·International Journal of Systematic and Evolutionary Microbiology·Takao IinoShigeaki Harayama
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Jan 31, 2020·Hospital Pediatrics·Craig A PressMark S Wainwright
Nov 11, 1999·Current Opinion in Neurology·O Stüve, S S Zamvil

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