PMID: 6977554Jul 1, 1981Paper

Serial measurement of nonspecific immune parameters in chronically hemodialyzed renal failure patients

Journal of Clinical Immunology
R H KermanB D Kahan

Abstract

Nonspecific immune monitoring of the percentage active T (A-T) rosette-forming cells (RFC) and spontaneous blastogenesis (SB) appear to be useful indexes of host reaction toward allografts. In order to assess the significance of the observed changes, renal failure patients were serially evaluated before and after hemodialysis for the percentage of total T (T-T) and A-T RFC and for peripheral blood leukocyte metabolic activity measured by a whole blood spontaneous blastogenesis (SB) assay. Renal failure patients had a significantly lower (P less than 0.05) percentage of T-T RFC than normal persons, while the percentage A-T RFC and SB remained stable. A hemodialysis treatment did not change the mean values of any of the three parameters. On the other hand, serial patient evaluation over 3 months revealed significant fluctuations in the percentage T-T RFC, but not the percentage A-T RFC and SB. Since the percentage A-T RFC and SB are relatively constant measures of immune status in ungrafted patients, significant changes in these nonspecific immune probes may reflect allograft rejection.

References

Jan 1, 1978·Journal of Dialysis·W E HoyR B Freeman
Apr 3, 1976·British Medical Journal·T TurszJ F Bach
Feb 27, 1975·The New England Journal of Medicine·H H FudenbergD Robbins
Jan 1, 1975·Journal of Immunological Methods·R SmithS Stefani
Nov 1, 1975·Cellular Immunology·D P SengarJ E Harris
May 17, 1973·The New England Journal of Medicine·J Wybran, H H Fudenberg
Apr 1, 1973·Clinical Immunology and Immunopathology·J WybranH H Fudenberg

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Citations

Jan 1, 1983·Vox Sanguinis·N BlumbergE Avila

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