Serial measurement of S100B and NSE in pediatric traumatic brain injury

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Dae-Won ParkSung-Kyoo Hwang

Abstract

Increased serum biomakers, such as S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE), are associated with traumatic brain injury (TBI). The purpose of this study is to investigate the serum levels of S100B and NSE in pediatric TBI patients and to predict a clinical outcome. Peripheral venous blood was collected within 6 h of injury and at 1 week to measure S100B and NSE. The serum S100B and NSE levels were measured using commercially available enzyme-linked immunosorbent assay kits. The authors divided participants into two groups at admission: a favorable group (patients with Glasgow Coma Scale [GCS] scores of 10-15) and an unfavorable group (patients with GCS scores of less than 9). Both S100B and NSE levels were compared between the two groups at the time of admission and 1 week later. Ten pediatric patients were enrolled (5 in the favorable group, 5 in the unfavorable group). The median serum S100B level of 134.21 pg/ml (range, 51.00-789.65 pg/ml) in patients with TBI at admission dropped to 41.49 pg/ml (range, 25.65-260.93 pg/ml) after 1 week, with significant differences between the traumatic event and 1 week later (p = 0.007). The median serum NSE level of 14.76 ng/ml (range, 6.48-21.23 ng/ml) in p...Continue Reading

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Citations

Mar 27, 2020·Frontiers in Molecular Neuroscience·Rong-Zheng MuYao-Jiang Huang
Mar 7, 2021·International Journal of Molecular Sciences·Baptiste BalançaAnne-Claire Lukaszewicz
Jun 26, 2021·Neurosurgical Review·Lucas Alexandre Santos MarzanoAline Silva de Miranda
Sep 28, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Derek J RobertsKerry B Goralski

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