PMID: 7372352Jan 1, 1980Paper

Serial measurements of systolic time intervals: effects of propranolol alone and combined with other agents in hypertensive patients

Hypertension
M C Kyle, E D Freis

Abstract

Systolic time intervals (STI) were recorded serially before and during 1 year of treatment in 367 hypertensive men. The patients were randomly assigned, double-blind, to one of the following regimens: propranolol alone (P), propranolol plus hydrochlorothiazide (P + T), propranolol plus hydralazine (P + H), propranolol plus hydrochlorothiazide plus hydralazine (P + T + H), or reserpine plus hydrochlorothiazide (R + T). Systolic time intervals were calculated by a computer pattern-recognition and measurement program. Diastolic blood pressure and heart rate (HR) decreased with each treatment regimen. The preejection period (PEP) was prolonged following P alone. The left ventricular ejection time (LVET), after correction for HR, was shortened with P + T and R + T and prolonged after P + H. The PEP/LVET was reduced with P + H. The prolongation of PEP during long-term administration of P is comparable with previous studies of its acute effects and suggests a moderate decrease in left ventricular performance. Calculation of STI also appears to be a useful method for showing the effects of adding other antihypertensive agents.

References

Jan 1, 1976·Australian and New Zealand Journal of Medicine·R C TaraziE L Bravo
Dec 1, 1976·Clinical Science and Molecular Medicine. Supplement·R C TaraziA P Niarchos
Feb 1, 1970·The American Journal of the Medical Sciences·D HuntG Hoffmann
Dec 1, 1970·Computers and Biomedical Research, an International Journal·M C Kyle, E D Freis
Jan 1, 1971·The American Journal of Cardiology·R F LeightonC F Wooley
Feb 1, 1968·Circulation·A M WeisslerC D Schoenfeld
Mar 1, 1968·Circulation·E D FrohlichI H Page
Apr 1, 1966·The American Journal of Cardiology·W S HarrisA M Weissler
Jan 1, 1958·Cardiologia : bollettino della Società italiana di cardiologia·W RAABY K STARCHESKA

❮ Previous
Next ❯

Citations

Jun 1, 1992·Journal of the American College of Nutrition·D E Grobbee
Feb 1, 1986·The American Journal of Cardiology·H BoudoulasA M Weissler
Sep 6, 2017·European Journal of Heart Failure·Tor Biering-SørensenScott D Solomon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.