Serial microPET measures of the metabolic reaction to a microdialysis probe implant

Journal of Neuroscience Methods
Wynne K SchifferStephen L Dewey

Abstract

Despite the widespread use of chronic brain implants in experimental and clinical settings, the effects of these long-term procedures on brain metabolism and receptor expression remain largely unknown. Under the hypothesis that intracerebral microdialysis transiently alters tissue metabolism, we performed a series of 18FDG microPET scans prior to and following surgical implantation of microdialysis cannulae. Parallel microPET measures using the competitive dopamine (DA) D2 receptor antagonist, 11C-raclopride, provided an assay of DA stability in these same animals. 18FDG scans were performed prior to microdialysis cannulation and again at 2, 12, 24, 48, 120, 168, 360 and 500 h (0.2, 0.5, 1, 2, 5, 7, 15 and 25 days). Separate animals received a sham surgery and the control group had no surgical intervention. For the first 24 h (scans at 2, 12 and 24 h post-surgery) uptake was reduced in both hemispheres. However, by 48 h, contralateral uptake had returned to pre-surgical levels. The striking finding was that from 48 to 500 h, the microdialysis cannulation produced widespread ipsilateral reductions in 18FDG uptake that encompassed the entire hemisphere. Despite the extent and persistence of these reductions, 11C-raclopride bindin...Continue Reading

References

Oct 1, 1978·The Journal of Comparative Neurology·R M Akers, H P Killackey
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BuczekH M Pappius
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M IngvarL Widén
Jun 1, 1989·Journal of Neurochemistry·H Benveniste
Jun 1, 1989·Metabolic Brain Disease·J L Lear, R F Ackermann
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1987·Acta Neuropathologica·H Benveniste, N H Diemer
Jan 1, 1995·Brain Research Bulletin·A W TogaK Ambach
Oct 1, 1995·Behavioural Brain Research·B H Westerink
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
May 8, 1998·Physics in Medicine and Biology·J QiT H Farquhar
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A H MooreS R Cherry
Mar 10, 2001·European Journal of Pharmacology·M R GerasimovS L Dewey
Jun 8, 2002·Current Pharmaceutical Design·S P Hume, R Myers
Oct 21, 2003·Current Neurology and Neuroscience Reports·Asita S SarrafzadehAndreas W Unterberg
Dec 3, 2003·Molecular Imaging·Andreas Markus Loening, Sanjiv Sam Gambhir
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·S Thomas CarmichaelHarley I Kornblum
Feb 28, 2004·Brain Research·Halleh M MirHarley I Kornblum
Mar 12, 2004·Nuclear Medicine and Biology·Hiroshi ToyamaRobert B Innis
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anat BiegonEsther Shohami

❮ Previous
Next ❯

Citations

May 17, 2006·Psychopharmacology·Wynne K SchifferStephen L Dewey
Apr 21, 2009·Nature Reviews. Neuroscience·Martin SarterW Matthew Howe
Nov 16, 2013·The Journal of Clinical Investigation·Michael MichaelidesYasmin L Hurd
Oct 10, 2006·The AAPS Journal·Onarae RiceSamuel John Gatley
Oct 21, 2015·Expert Opinion on Drug Discovery·Wilhelmus E A de WitteElizabeth C M de Lange
Jan 11, 2014·Nuclear Medicine and Biology·Stergios TsartsalisPhilippe Millet
Nov 28, 2015·ELife·Hongyoon ChoiDong Soo Lee
Apr 13, 2010·Neurobiology of Disease·Martine M MirrioneStella E Tsirka
Dec 18, 2015·ACS Chemical Neuroscience·Martin Georg StreblJacob M Hooker
Oct 12, 2015·Nuclear Medicine and Biology·Stergios TsartsalisPhilippe Millet
Mar 10, 2007·Brain Research·David B FrumbergWynne K Schiffer
Apr 30, 2015·Psychopharmacology·Sjoerd J FinnemaSarah Grimwood
Apr 29, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Joke ParthoensSteven Staelens
Jun 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael S PlaczekJacob M Hooker
Apr 5, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Pablo BascuñanaMiguel Ángel Pozo
Apr 9, 2015·EJNMMI Research·Stergios TsartsalisPhilippe Millet
Nov 2, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nathalie Van Den BergeRoel Van Holen
Mar 18, 2015·European Journal of Medicinal Chemistry·Nathalie FresneauFrédéric Fabis
Jul 1, 2016·Journal of Sleep Research·David ElmenhorstAndreas Bauer
Apr 11, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni C SantoroStephen L Dewey
Jun 30, 2009·Journal of Neuroscience Methods·Andrea Jaquins-Gerstl, Adrian C Michael
Feb 17, 2017·IEEE Transactions on Medical Imaging·Alan MirandaJeroen Verhaeghe
May 30, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Céline NicolasMarcello Solinas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2021 Meta ULC. All rights reserved