Serial monitoring of interleukin-1beta, soluble interleukin-2 receptor and lipopolysaccharide binding protein levels after death A comparative evaluation of potential postmortem markers of sepsis

International Journal of Legal Medicine
U ReicheltMichael Tsokos

Abstract

We prospectively monitored the postmortem course of interleukin-1beta (IL-1beta), soluble interleukin-2 receptor (sIL-2R) and lipopolysaccharide binding protein (LBP) in septic and non-septic fatalities to evaluate their potential as biochemical postmortem markers of sepsis. Serum concentrations were determined by chemiluminescent immunometric assays. In both the sepsis group and the control group a postmortem increase of IL-1beta levels with the progression of time after death was observed, in both groups mainly starting from the reference concentration of healthy individuals (5 pg/ml) and with no significant differences at later time points postmortem. SIL-2R (reference limit 1,000 U/ml) was highly elevated in all individuals included in the sepsis group at all time points postmortem with statistically significant differences between the sepsis and control groups (p<0.01). An excessive postmortem decrease of sIL-2R serum levels associated with progression of time after death was observed in all cases included in the sepsis group in contrast to just 1 out of 16 control cases. LBP (reference limit <10 g/ml) was elevated in all sepsis cases whereas in the control group LBP levels were below 10 microg/ml in 88%. The postmortem ti...Continue Reading

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Citations

Apr 6, 2006·International Journal of Legal Medicine·Sohtaro MimasakaMasato Funayama
Nov 23, 2013·Legal Medicine·Cristian Palmiere, Marc Augsburger
May 24, 2014·Virchows Archiv : an International Journal of Pathology·Kunihiro InaiHironobu Naiki
Jun 3, 2006·International Journal of Legal Medicine·Vittorio FineschiEmanuela Turillazzi
Dec 3, 2014·Journal of Forensic and Legal Medicine·Cristian Palmiere, Coraline Egger
Oct 11, 2011·International Journal of Legal Medicine·Cristian Palmiere, Patrice Mangin
Oct 16, 2012·International Journal of Legal Medicine·Marc AugsburgerCristian Palmiere
Dec 25, 2012·International Journal of Legal Medicine·Cristian PalmierePatrice Mangin
Jan 30, 2013·Forensic Science International : Synergy·Cristian PalmiereDominique Werner
Jul 13, 2016·Journal of Forensic Sciences·Cristian PalmiereGilbert Greub
Sep 8, 2009·Forensic Science International : Synergy·Jun-Ling AnToshikazu Kondo
Jun 22, 2006·Forensic Science International : Synergy·Michael Tsokos
Feb 18, 2006·Microbes and Infection·Janine ZweignerJoerg R Weber
May 1, 2016·Journal of Forensic and Legal Medicine·S L Belsey, R J Flanagan
Sep 10, 2013·The Journal of Infection·Cristian PalmiereMarc Augsburger
May 31, 2016·Mediators of Inflammation·C PomaraE Turillazzi
Oct 31, 2019·Antibiotics·Lucia TattoliBiagio Solarino
Oct 24, 2020·Diagnostics·Chiara StassiElvira Ventura Spagnolo
Jun 11, 2008·Forensic Science International : Synergy·Takaki IshikawaHitoshi Maeda

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