PMID: 6111497Mar 1, 1981Paper

Serial monitoring of serum estradiol and progesterone levels during the HMG-HCG therapy in sex anovulatory women

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
N SakuragiK Ichinoe

Abstract

Serum estradiol (E2) and progesterone (P) levels were radioimmunoassayed every or every other day for monitoring the HMG-HCG therapy in six anovulatory patients, and the clinical significance of measuring steroid hormones as precautionary counterplot against the ovarian hyperstimulation syndrome and multiple pregnancies was evaluated. Administration of HCG is recommended to trigger ovulation when serum E2 levels reach 400-600 pg/ml. Mean peak P level in 7-8 days after ovulation induced by HMG-HCG was 22.9 ng/ml, which is significantly higher than P levels of the same period in spontaneous and clomiphene-induced ovulations. This result suggests that there may occur multiple ovulations which result in multiple pregnancies in HMG-HCG therapy.

References

Sep 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H H McGarrigleG I Swyer
Jul 15, 1974·American Journal of Obstetrics and Gynecology·T AonoK Kurachi
Mar 20, 1973·Nihon Naibunpi Gakkai zasshi·T Makino
Sep 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M M Shaaban, A Klopper
Sep 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M M Shaaban, A Klopper
Apr 1, 1974·The Journal of Clinical Endocrinology and Metabolism·S G KorenmanB M Sherman
Dec 1, 1971·American Journal of Obstetrics and Gynecology·I H ThorneycroftR M Nakamura

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