Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death

Annals of Neurology
Céline M DubéTallie Z Baram

Abstract

Whereas most febrile seizures (FSs) carry a benign outcome, a subpopulation of individuals with prolonged FSs are at risk for later temporal lobe epilepsy. Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis in such individuals. Here, we used serial MRIs, obtained before and at several time points after experimental prolonged FSs, to determine the prevalence and distribution of signal changes on T2-weighted images and to investigate the pathological substrates leading to these changes. Seventy-five percent of immature rats with experimental prolonged FSs had abnormal T2 signal enhancement at 24 hours, and 87.5% at 8 days after the seizures. The altered T2 values involved the dorsal hippocampus (75%), the piriform cortex (87.5%), and the amygdala (25%). However, these changes were not accompanied by evidence of neuronal injury or death in these regions, as assessed using the Fluoro-Jade method. Thus, experimental prolonged FSs lead to relatively frequent abnormal MRI signal in "temporal lobe" structures. Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. .

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Citations

May 15, 2013·Neurochemistry International·Andre Obenaus
Jul 7, 2009·Nature Reviews. Neurology·Sanjay N Rakhade, Frances E Jensen
Feb 1, 2006·Brain : a Journal of Neurology·Céline DubéTallie Z Baram
Jan 19, 2006·Epilepsia·Bianca JuppTerence J O'Brien
Jun 16, 2007·Epilepsia·Asla PitkänenJari Nissinen
Jun 16, 2007·Epilepsia·Morris H ScantleburySolomon L Moshé
Oct 6, 2007·Epilepsia·Hal Blumenfeld
Dec 12, 2007·Epilepsia·Dale C HesdorfferVeronica J Hinton
Nov 28, 2009·Epilepsia·Sophie HamelinAntoine Depaulis
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Céline M DubéTallie Z Baram
Mar 22, 2008·AJR. American Journal of Roentgenology·James M ProvenzaleDarrell V Lewis
Sep 10, 2013·International Journal of Molecular Sciences·Doodipala Samba Reddy, Ramkumar Kuruba
Feb 4, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sandy R ShultzRuben I Kuzniecky
Mar 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katelin P PattersonShlomo Shinnar
Dec 8, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aylin Y ReidQuentin J Pittman
Feb 10, 2011·Neuroscience Letters·Asht Mangal MishraHal Blumenfeld
Aug 24, 2010·Seminars in Pediatric Neurology·Saba Ahmad, Eric D Marsh
Nov 13, 2008·Experimental Neurology·Céline M DubéGregory L Holmes
Aug 19, 2008·Neurobiology of Disease·Jacobus F A JansenGovert Hoogland
Feb 19, 2008·Pediatric Neurology·Gregory L Holmes, Qian Zhao
Sep 28, 2007·Trends in Neurosciences·Céline M DubéTallie Z Baram
Jun 9, 2005·Annals of Neurology·Morris H ScantleburyLionel Carmant
May 28, 2011·Acta Neurologica Scandinavica·M T AcostaW H Theodore
Jul 22, 2010·The European Journal of Neuroscience·Robbert G E NotenboomPierre N E de Graan
Feb 10, 2006·Journal of Neuroscience Methods·Bianca JuppTerence J O'Brien
May 6, 2015·Experimental Neurology·Jeremy M BarryGregory L Holmes

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