PMID: 8588058Jul 1, 1995

Serial partial sleep deprivation as adjuvant treatment of depressive insomnia

Progress in Neuro-psychopharmacology & Biological Psychiatry
U HemmeterE Holsboer-Trachsler


1. Sleep disturbance is a prominent symptom of major depression. Despite specific treatment with antidepressants, there is a substantial number of patients who improve in depressed mood but remain sleep disturbed. 2. Polysomnographic sleep (PSG) data and self reported sleep measures were assessed at baseline and after one week in 18 patients (35-65 years) randomly assigned to treatment with either trimipramine alone 200 mg/d (group 1) or trimipramine (200 mg/d) and additional serial partial sleep deprivation in the second half of the night (3x/week) (group 2). 3. In group 1 no marked changes between baseline and after treatment were found. 4. In group 2 the PSG data showed a significant increase of slow wave sleep and a compensatory decrease in stage 1. Sleep continuity improved in terms of numbers of awakenings, sleep onset latency and total sleep time. These changes were in parallel with the subjective estimation of sleep in group 2. 5. There was no significant difference in the Hamilton rating scale scores neither at baseline nor after treatment. 6. These observed effects on sleep following additional serial PSD therapy seem to occur independent from the antidepressive effect.


Jan 1, 1990·The American Journal of Psychiatry·J C Wu, William E Bunney
Jan 1, 1986·Psychopathology·E Holsboer-Trachsler, K Ernst
Jan 1, 1982·Journal of Psychiatric Research·S Elsenga, R H van den Hoofdakker
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·E Holsboer-Trachsler, E Seifritz


Aug 28, 1998·Journal of Psychosomatic Research·J S Carpenter, M A Andrykowski
Jun 20, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·V S RotenbergY Melamed
Dec 17, 2008·Sleep Medicine·Ruth M Benca, Michael J Peterson
May 1, 2007·Journal of Psychosomatic Research·Kyriaki MystakidouLambros Vlahos
Nov 27, 2004·Psychosomatic Medicine·Bernd KundermannStefan Lautenbacher

Related Concepts

Tricyclic Antidepressive Agents
Combined Modality Therapy
Transient Insomnia
Factor Construct Rating Scales (Fcrs)
Insufficient Sleep Syndrome
Sleep Stages
Trimipramine, (-)-Isomer

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