PMID: 2506381Jul 1, 1989Paper

Serial plasma and urinary aluminum levels and tissue loading in preterm twins

JPEN. Journal of Parenteral and Enteral Nutrition
M E BozynskiE J Wright

Abstract

Serial plasma, urinary, and postmortem tissue aluminum levels were determined in 32-week, appropriate-for-gestational-age twins from 45 to 151 days postnatal age. Estimated total aluminum absorptions were 56.7 mg, and 28 mg, twin A and twin B, respectively. At autopsy, Twin A had a hypoplastic right kidney while Twin B had normal kidneys. Mean plasma aluminum levels (twin A, 34.2 micrograms/liter and twin B, 32.3 micrograms/liter) and urinary aluminum levels expressed as aluminum creatinine ratios (twin A, 11.3 and twin B, 8.5) were similar. These levels were elevated compared to normal plasma aluminum levels of 5.1 +/- 3.6 (1 SD) and urinary aluminum creatinine ratios of 0.64 +/- 0.75 (1 SD). Twin A had higher tissue aluminum levels than twin B in all tissues except for brain. Bone and liver aluminum contents for both twins were increased as compared to infants receiving short-term or no parenteral nutrition. We conclude; (1) tissue aluminum loading occurs in infants receiving aluminum-containing solutions, (2) plasma and urinary aluminum levels are poor predictors of tissue aluminum content, (3) enteral solutions may add significant aluminum exposure.

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Citations

Jul 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A Sedman
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Sep 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Victoria Lima-RogelGilberto Fabian Hurtado-Torres
Mar 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·D BougleJ F Duhamel
Jan 1, 1994·Acta Paediatrica·A MorenoA Ballabriga
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
Mar 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Emmanuelle AdvenierOdile Corriol
Jul 1, 1996·Medical and Pediatric Oncology·V S KanwarW L Furman

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