Serial plasma metabolites following hypoxic-ischemic encephalopathy in a nonhuman primate model

Developmental Neuroscience
Pattaraporn T ChunSandra E Juul

Abstract

Biomarkers that indicate the severity of hypoxic-ischemic brain injury and response to treatment and that predict neurodevelopmental outcomes are urgently needed to improve the care of affected neonates. We hypothesize that sequentially obtained plasma metabolomes will provide indicators of brain injury and repair, allowing for the prediction of neurodevelopmental outcomes. A total of 33 Macaca nemestrina underwent 0, 15 or 18 min of in utero umbilical cord occlusion (UCO) to induce hypoxic-ischemic encephalopathy and were then delivered by hysterotomy, resuscitated and stabilized. Serial blood samples were obtained at baseline (cord blood) and at 0.1, 24, 48, and 72 h of age. Treatment groups included nonasphyxiated controls (n = 7), untreated UCO (n = 11), UCO + hypothermia (HT; n = 6), and UCO + HT + erythropoietin (n = 9). Metabolites were extracted and analyzed using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry and quantified by PARAFAC (parallel factor analysis). Using nontargeted discovery-based methods, we identified 63 metabolites as potential biomarkers. The changes in metabolite concentrations were characterized and compared between treatment groups. Further compariso...Continue Reading

Citations

Jul 8, 2015·Neurochemical Research·Mary C McKennaCourtney L Robertson
Mar 28, 2017·Progress in Neurobiology·Julianna KardosMiklós Palkovits
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·M BarkhuizenA W D Gavilanes
Jan 19, 2018·Current Opinion in Pediatrics·Ernest M GrahamFrances J Northington
Apr 9, 2020·Metabolites·Emanuela LocciErnesto d'Aloja
Jul 15, 2021·BioMed Research International·Yanjuan JiaLi Wei

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