Serial prostatic biopsies in men with persistently elevated serum prostate specific antigen values

The Journal of Urology
D W KeetchD S Smith

Abstract

The objective of this study was to determine the need for repeat prostatic biopsies in men whose initial biopsy results revealed no evidence of cancer or atypia. We evaluated 1,136 men who underwent 1 or more prostatic biopsies in a longitudinal prostate specific antigen (PSA) based prostate cancer screening study that called for biopsy if the serum PSA level was greater than 4.0 ng./ml. (Hybritech assay) and findings on rectal examination or ultrasonography were abnormal or suspicious for cancer. Of the 1,136 men who underwent prostatic biopsy 391 (34%) had prostate cancer on the initial biopsy. Of 427 men who had negative initial biopsy results, a persistent serum PSA level of greater than 4.0 ng./ml. and abnormal rectal or ultrasound examination findings 82 (19%) had cancer on biopsy 2. Of 203 men with persistent abnormalities 16 (8%) had cancer on biopsy 3 and 6 of 91 (7%) had cancer on biopsy 4 or later. Thus, 96% of the cancers were detected through either biopsy 1 or 2. The median initial PSA level, followup PSA levels and the yearly rate of change in PSA were significantly greater in men whose cancer was detected compared with those of men whose cancer was not detected (6.4 versus 5.4 ng./ml., 7.4 versus 6.6 ng./ml. and...Continue Reading

References

Mar 1, 1992·The Journal of Urology·M K BrawerP H Lange
Mar 1, 1992·The Journal of Urology·F LabrieJ Emond
Apr 25, 1991·The New England Journal of Medicine·W J CatalonaG L Andriole
May 1, 1989·The Journal of Urology·G W ChodakH W Schoenberg
Oct 1, 1984·The Journal of Urology·I M ThompsonC R Spence

❮ Previous
Next ❯

Citations

Aug 1, 1996·The New England Journal of Medicine·T O MorganJ W Moul
Oct 23, 1997·The Journal of Urology·D S SmithW J Catalona
Jun 8, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·M KojimaY Hayase
Mar 29, 2001·Radiology·E J HalpernL G Gomella
Jun 27, 2002·Current Urology Reports·D K Ornstein, J Kang
Sep 13, 2003·Prostate Cancer and Prostatic Diseases·R DamianoM D'Armiento
Sep 23, 2003·The Journal of Urology·Ernesto Lopez-CoronaMichael W Kattan
Aug 18, 2004·The Journal of Urology·Maurizio BrausiAnna Maria Cesinaro
Jun 14, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazumasa MatsumotoShiro Baba
Aug 8, 2006·The Journal of Urology·Brent V YankeIvan Colon
Oct 13, 2006·BJU International·Simon R J BottBruce S I Montgomery
Aug 19, 2007·Current Treatment Options in Oncology·J Stephen Jones
Nov 7, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Luciano NesrallahMiguel Srougi
Jan 13, 2011·BJU International·Carvell T Nguyen, J Stephen Jones
Mar 5, 2011·Urologia Internationalis·Francesco PintoPierFrancesco Bassi
Aug 23, 2012·Nature Reviews. Clinical Oncology·Olivier RouvièreJean-Yves Chapelon
Mar 4, 2014·The Journal of Urology·Christopher B RiedingerUNKNOWN Michigan Urological Surgery Improvement Collaborative

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.