PMID: 2507612Oct 1, 1989Paper

Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: efficacy for noninvasive assessment of thrombolytic therapy

Journal of the American College of Cardiology
F J WackersB L Zaret

Abstract

Technetium-99m isonitrile is a new myocardial perfusion imaging agent that accumulates according to the distribution of myocardial blood flow. However, unlike thallium-201, it does not redistribute over time. This imaging agent was used with serial quantitative planar imaging to assess the initial risk area of infarction, its change over time and the relation to infarct-related artery patency in 30 patients with a first acute myocardial infarction. Twenty-three of 30 patients were treated with recombinant tissue-type plasminogen activator (rt-PA) within 4 h after the onset of chest pain. Seven patients were treated in the conventional manner without thrombolytic therapy. Technetium-99m isonitrile was injected before or at the initiation of thrombolytic therapy, and imaging was performed several hours later. These initial images demonstrated the area at risk. Repeat imaging was performed 18 to 48 h later and at 6 to 14 days after the onset of myocardial infarction to visualize the ultimate extent of infarction. The initial area at risk varied greatly (range defect integral 2 to 61) both in patients treated with rt-PA and in those who received conventional treatment. For the total group, the initial imaging defect decreased in si...Continue Reading

References

Jul 1, 1976·The New England Journal of Medicine·F J WackersH J Wellens
Oct 1, 1989·Circulation·L GibbonsK Cooper
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Aug 1, 1988·The American Journal of Cardiology·J E DalenG Knatterud
Dec 1, 1988·Journal of the American College of Cardiology·H KiatJ Friedman
Apr 1, 1988·Journal of the American College of Cardiology·J L RitchieJ W Kennedy
Apr 21, 1988·The American Journal of Cardiology·G A Beller
Oct 1, 1986·Journal of the American College of Cardiology·W S Weintraub, R H Helfant
Mar 1, 1987·Journal of the American College of Cardiology·G A Beller
Mar 1, 1987·The American Journal of Cardiology·B J KircherB Pitt
Apr 1, 1987·The American Journal of Cardiology·D H SchaerA M Ross
Jan 1, 1985·Seminars in Nuclear Medicine·F J WackersJ P Clements
Apr 15, 1986·The American Journal of Cardiology·M W KrucoffC E Rackley
Mar 1, 1985·Journal of the American College of Cardiology·J SchoferD G Mathey

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Citations

Feb 1, 1993·Clinical Cardiology·G A Beller
Jul 1, 1993·Clinical Cardiology·M Ragosta, G A Beller
Jul 1, 1996·European Journal of Nuclear Medicine·G Hör
Jan 1, 1992·International Journal of Cardiac Imaging·A S Iskandrian, J Heo
Mar 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H L HaronianF J Wackers
May 1, 1997·Annals of Nuclear Medicine·N TamakiJ Konishi
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Seishi NakamuraToshiji Iwasaka
Feb 1, 1995·The American Journal of Cardiology·D ZahgerP K Shah
Jun 1, 1991·Journal of the American College of Cardiology·G V Martin, J L Ritchie
Jan 1, 1992·Journal of the American College of Cardiology·K C HuberR J Gibbons
May 1, 1993·Journal of the American College of Cardiology·L I HellerJ A Leppo
May 1, 1993·Journal of the American College of Cardiology·E H Botvinick
Nov 1, 1993·Journal of the American College of Cardiology·H G Olson
Mar 1, 1995·Journal of the American College of Cardiology·C MarcassaP Giannuzzi
Apr 1, 1994·Journal of the American College of Cardiology·T C HiltonS A Stowers
Jul 1, 1996·Journal of the American College of Cardiology·P P VerhoevenF J Wackers
May 1, 1991·Journal of the American College of Cardiology·T F ChristianB J Gersh
Sep 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T F Christian
May 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T F ChristianR J Gibbons
Jul 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·P MarzulloA L'Abbate
Mar 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L A MortelmansF J Van de Werf
Mar 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T Nishimura
Jan 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L I HellerJ A Leppo

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