PMID: 15394070Dec 1, 1949Paper

Serial renal clearances in dogs with nephrogenic and spontaneous hypertension

The Journal of Experimental Medicine
J STAMLERS RODBARD

Abstract

Evidence is presented on the occurrence of spontaneous hypertension in dogs. All dogs with spontaneous hypertension exhibited normal renal plasma flow and glomerular filtration rate. Clearances on nephrogenic hypertensive dogs revealed that some exhibited normal kidney function, while others had significant depression of renal plasma flow and glomerular filtration rate. In the latter, the filtration fraction may or may not be elevated. Serial renal clearances were done at intervals on 3 dogs with spontaneous hypertension during their 3rd year of known hypertension. They exhibited no tendency to develop impaired renal function in the face of prolonged benign hypertension. Serial renal clearances on nephrogenic hypertensive dogs revealed no tendency for kidney function to become progressively impaired. This was true, whether the immediate postoperative clearance values were normal or depressed. It was also true regardless of the duration of the hypertension. It is suggested that mechanisms other than elevated blood pressure per se operate to produce progressive kidney damage and impairment of renal function. No tendency was revealed over the course of a year or more for the kidney function to improve in Goldblatt dogs exhibiting ...Continue Reading

Citations

May 1, 1950·The Journal of Clinical Investigation·A P FISHMANL RUBENSTEIN
Jan 1, 1997·Renal Failure·A R MichellA Gleadhill
Nov 1, 1951·Circulation·A H WILLIAMS, H A SCHROEDER
Oct 1, 1954·The Journal of Pathology and Bacteriology·B BRONTE-STEWART, R H HEPTINSTALL
Sep 8, 1965·Annals of the New York Academy of Sciences·H M PirieE W Fisher

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