Serial T-SPOT.TB and quantiFERON-TB-Gold In-Tube assays to monitor response to antitubercular treatment in Italian children with active or latent tuberculosis infection

The Pediatric Infectious Disease Journal
Elena ChiappiniMaurizio de Martino

Abstract

We performed a prospective study to investigate T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-G-IT) dynamics during antitubercular treatment in active tuberculosis (TB) or latent TB. Eighteen children with latent TB and 26 with TB were enrolled. At 6 months of follow-up reversion rate was 5.88% (95% CI:0-13.79) for QFT-G-IT; 9.09% (95% CI:0.59-17.58) for T-SPOT.TB (P=0.921) in TB cases. Significant decline in quantitative response was observed exclusively in TB cases. Our results suggest that serial IGRA have limited use in children receiving antitubercular treatment.

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Citations

Jun 1, 2016·International Journal of Mycobacteriology·Najeeha Talat IqbalGhaffar Dawood
Oct 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E ChiappiniUNKNOWN Italian Pediatric TB Study Group
Jun 3, 2014·The Tohoku Journal of Experimental Medicine·Kwang Won SeoYangjin Jegal
May 25, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Thuli MthiyaneKeertan Dheda
Jan 12, 2017·Expert Review of Anti-infective Therapy·E VenturiniL Galli
Apr 4, 2017·Japanese Journal of Infectious Diseases·Thana KhawcharoenpornAnucha Apisarnthanarak
Dec 31, 2019·Journal of Immunology Research·Eleane de OyarzabalMartha Torres
Jul 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara SulimanThomas J Scriba
Oct 6, 2020·Frontiers in Immunology·Claudia CarranzaMartha Torres
Nov 27, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Qingluan YangWenhong Zhang

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